Abstract
Breast cancer is a major disease affecting women in industrialized countries, for whom the lifetime risk exceeds 10%. In the US, breast cancer affects one in eight women.1 Ovarian cancer is substantially less common than breast cancer, with a lifetime risk of 1.6% for women in industrialized countries2; however, it is one of the most lethal gynecological malignancies. It is estimated that 5%-10% of breast and invasive ovarian cancer cases are hereditary and attributable to mutations in several highly penetrant susceptibility genes.3,4 Inherited susceptibility has already been recognized as a significant risk factor for cancers of the breast and female genital organs.
Original language | English (US) |
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Title of host publication | Current Topics in Human Genetics |
Subtitle of host publication | Studies in Complex Diseases |
Publisher | World Scientific Publishing Co. |
Pages | 773-786 |
Number of pages | 14 |
ISBN (Electronic) | 9789812790811 |
ISBN (Print) | 9812704728, 9789812704726 |
DOIs | |
State | Published - Jan 1 2007 |
ASJC Scopus subject areas
- General Agricultural and Biological Sciences
- General Biochemistry, Genetics and Molecular Biology
- General Medicine