Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis

Changying Jiang; Ying T. Hwang; Guangliang Wang; John C.W. Randell; Donald M. Coen; Charles B.C. Hwang

doi:10.1128/JVI.01133-07

Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis

Changying Jiang, Ying T. Hwang, Guangliang Wang, John C.W. Randell, Donald M. Coen, Charles B.C. Hwang

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Herpes simplex virus mutants with single substitutions that decrease DNA binding by the DNA polymerase processivity subunit UL42 are only modestly impaired for viral replication. In this study, recombinant viruses harboring two or four of these mutations were constructed. The more substitutions, the more severe the defects in viral replication and DNA synthesis, suggesting that DNA binding by UL42 is important for these processes.

Original language	English (US)
Pages (from-to)	12077-12079
Number of pages	3
Journal	Journal of Virology
Volume	81
Issue number	21
DOIs	https://doi.org/10.1128/JVI.01133-07
State	Published - Nov 2007
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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abstract = "Herpes simplex virus mutants with single substitutions that decrease DNA binding by the DNA polymerase processivity subunit UL42 are only modestly impaired for viral replication. In this study, recombinant viruses harboring two or four of these mutations were constructed. The more substitutions, the more severe the defects in viral replication and DNA synthesis, suggesting that DNA binding by UL42 is important for these processes.",

author = "Changying Jiang and Hwang, {Ying T.} and Guangliang Wang and Randell, {John C.W.} and Coen, {Donald M.} and Hwang, {Charles B.C.}",

year = "2007",

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AU - Jiang, Changying

AU - Hwang, Ying T.

AU - Wang, Guangliang

AU - Randell, John C.W.

AU - Coen, Donald M.

AU - Hwang, Charles B.C.

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N2 - Herpes simplex virus mutants with single substitutions that decrease DNA binding by the DNA polymerase processivity subunit UL42 are only modestly impaired for viral replication. In this study, recombinant viruses harboring two or four of these mutations were constructed. The more substitutions, the more severe the defects in viral replication and DNA synthesis, suggesting that DNA binding by UL42 is important for these processes.

AB - Herpes simplex virus mutants with single substitutions that decrease DNA binding by the DNA polymerase processivity subunit UL42 are only modestly impaired for viral replication. In this study, recombinant viruses harboring two or four of these mutations were constructed. The more substitutions, the more severe the defects in viral replication and DNA synthesis, suggesting that DNA binding by UL42 is important for these processes.

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Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis

Abstract

ASJC Scopus subject areas

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