TY - JOUR
T1 - Hesr, a mediator of the motch signaling, functions in heart and vessel development
AU - Kokubo, Hiroki
AU - Miyagawa-Tomita, Sachiko
AU - Johnson, Randy L.
N1 - Funding Information:
The authors thank Dr. Yumiko Saga and the members of her laboratory at the National Institute of Genetics, Mishima, and Dr. Yasumi Nakashima of Tokyo Women's Medical University, Tokyo, for support and helpful criticism. We also thank Dr. Reedy M.V. of Creighton University, NE, for critical reading of the manuscript and Ms. Barbara Levene for English correction. This work was supported by research grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2005/7
Y1 - 2005/7
N2 - Hesr genes are members of the hairy and enhancer of split-related (hesr) gene family of basic helix-loop-helix-type transcriptional repressors. hesr genes have been implicated in cardiovascular development as the primary targets of Notch signaling. Functional analysis of hesr2 knockout mice revealed abnormal cardiac hemodynamics, such as atrioventricular valve regurgitation and reduced left ventricular systolic function, caused by hypoplastic AV valves and abnormal cardiomyocytes. Recent evidence demonstrates that hesr1 and hesr2 function redundantly in epithelial-to-mesenchymal transformation during atrioventricular valve formation and maintenance of trabecular cells in the heart ventricles, and in arterial-venous differentiation of blood vessels. This review highlights the many functions of the hesr gene family in heart and vessel development.
AB - Hesr genes are members of the hairy and enhancer of split-related (hesr) gene family of basic helix-loop-helix-type transcriptional repressors. hesr genes have been implicated in cardiovascular development as the primary targets of Notch signaling. Functional analysis of hesr2 knockout mice revealed abnormal cardiac hemodynamics, such as atrioventricular valve regurgitation and reduced left ventricular systolic function, caused by hypoplastic AV valves and abnormal cardiomyocytes. Recent evidence demonstrates that hesr1 and hesr2 function redundantly in epithelial-to-mesenchymal transformation during atrioventricular valve formation and maintenance of trabecular cells in the heart ventricles, and in arterial-venous differentiation of blood vessels. This review highlights the many functions of the hesr gene family in heart and vessel development.
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U2 - 10.1016/j.tcm.2005.05.005
DO - 10.1016/j.tcm.2005.05.005
M3 - Review article
C2 - 16165016
AN - SCOPUS:24744460910
SN - 1050-1738
VL - 15
SP - 190
EP - 194
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 5
ER -