TY - JOUR
T1 - Heterogeneity of cell lineages in L3 leukemias
AU - Koziner, B.
AU - Mertelsmann, R.
AU - Andreeff, M.
AU - Arlin, Z.
AU - Hansen, H.
AU - De Harven, E.
AU - McKenzie, S.
AU - Gee, T.
AU - Good, R. A.
AU - Clarkson, B.
PY - 1980
Y1 - 1980
N2 - Five cases of adult leukemia with L3 morphology in bone marrow were studied for the presence of immunologic, metabolic, and enzymatic markers. Among the 5 patients, there were 4 males and 1 female. Median age was 66 with a range of 16-80 yr. Median survival was only 5 mth. Serum lactate dehydrogenase (LDH) levels, 3H-thymidine labeling indices, and DNA/RNA content of the L3 lymphoblasts were markedly elevated. B-cell markers were found in 3 cases, 2 exhibiting surface membrane IgM-λ, and 1 IgG-K. Terminal deoxynucleotidyl transferase (TdT) enzymatic activity was consistently low in this group. In 1 case, the L3 lymphoblasts displayed only surface Fc receptors demonstrated by the binding of aggregated IgG. TdT activity was found to be significantly increased. In another instance, the lymphoblasts formed spontaneous rosettes with sheep erythrocytes and exhibited paranuclear staining with acid phosphatase. TdT activity was found to be low. Although most of the L3 leukemias are neoplasias of B lymphocytes, other lineages may also express this morphology.
AB - Five cases of adult leukemia with L3 morphology in bone marrow were studied for the presence of immunologic, metabolic, and enzymatic markers. Among the 5 patients, there were 4 males and 1 female. Median age was 66 with a range of 16-80 yr. Median survival was only 5 mth. Serum lactate dehydrogenase (LDH) levels, 3H-thymidine labeling indices, and DNA/RNA content of the L3 lymphoblasts were markedly elevated. B-cell markers were found in 3 cases, 2 exhibiting surface membrane IgM-λ, and 1 IgG-K. Terminal deoxynucleotidyl transferase (TdT) enzymatic activity was consistently low in this group. In 1 case, the L3 lymphoblasts displayed only surface Fc receptors demonstrated by the binding of aggregated IgG. TdT activity was found to be significantly increased. In another instance, the lymphoblasts formed spontaneous rosettes with sheep erythrocytes and exhibited paranuclear staining with acid phosphatase. TdT activity was found to be low. Although most of the L3 leukemias are neoplasias of B lymphocytes, other lineages may also express this morphology.
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U2 - 10.1182/blood.v55.4.694.694
DO - 10.1182/blood.v55.4.694.694
M3 - Article
C2 - 6244017
AN - SCOPUS:0018865540
SN - 0006-4971
VL - 55
SP - 694
EP - 698
JO - Blood
JF - Blood
IS - 4
ER -