TY - JOUR
T1 - Heterotypic cellular interactions in the ovarian tumor microenvironment
T2 - Biological significance and therapeutic implications
AU - Naora, Honami
PY - 2014
Y1 - 2014
N2 - The majority of women who are diagnosed with epithelial ovarian cancer present with extensive peritoneal carcinomatosis and are rarely cured by conventional chemotherapy. Ovarian cancer cells typically disseminate by shedding into the peritoneal fluid and implant on the mesothelium-lined peritoneal surfaces that overlie connective and white adipose tissues. Emerging evidence indicates that ovarian tumor progression is orchestrated by dynamic interplay between tumor cells and a variety of stromal cells such as adipocytes, endothelial cells, fibroblasts, mesenchymal stem cells, macrophages, and other immune cells. This mini-review discusses the biological significance of the heterotypic cellular interactions in the ovarian tumor microenvironment and the therapeutic implications of targeting these interactions.
AB - The majority of women who are diagnosed with epithelial ovarian cancer present with extensive peritoneal carcinomatosis and are rarely cured by conventional chemotherapy. Ovarian cancer cells typically disseminate by shedding into the peritoneal fluid and implant on the mesothelium-lined peritoneal surfaces that overlie connective and white adipose tissues. Emerging evidence indicates that ovarian tumor progression is orchestrated by dynamic interplay between tumor cells and a variety of stromal cells such as adipocytes, endothelial cells, fibroblasts, mesenchymal stem cells, macrophages, and other immune cells. This mini-review discusses the biological significance of the heterotypic cellular interactions in the ovarian tumor microenvironment and the therapeutic implications of targeting these interactions.
KW - Adipocytes
KW - Endothelial cells
KW - Fibroblasts
KW - Macrophages
KW - Mesenchymal stem cells
KW - Mesothelium
KW - Ovarian cancer
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=84898005205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898005205&partnerID=8YFLogxK
U2 - 10.3389/fonc.2014.00018
DO - 10.3389/fonc.2014.00018
M3 - Short survey
C2 - 24567915
AN - SCOPUS:84898005205
SN - 2234-943X
VL - 4 FEB
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 00018
ER -