TY - JOUR
T1 - Hexamethylmelamine chemotherapy for disseminated endometrial cancer
AU - Seski, Jan C.
AU - Edwards, Creighton L.
AU - Copeland, Larry J.
AU - Gershenson, David M.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1981/9
Y1 - 1981/9
N2 - To evaluate the role of hexamethylmelamine (HMM) in the treatment of endometrial cancer, 20 women with metastatic or recurrent endometrial carcinoma received HMM orally at a dose of 8 mg/kg/day. Six patients (30%) showed a partial response, with a median duration of response of 3.5 months and a range of 1 to 7 months. Two patients responded to HMM as a second-line agent following previous treatment with nonhormonal chemotherapy. There were no complete responses. The major toxicities noted with HMM therapy were nausea, vomiting, and neurotoxicity. In 6 patients (30%), therapy with HMM was discontinued because of toxicity. Although HMM is active against endometrial cancer when given at a dose of 8 mg/ kg/day, it appears to have limited usefulness because toxicity precludes its prolonged administration.
AB - To evaluate the role of hexamethylmelamine (HMM) in the treatment of endometrial cancer, 20 women with metastatic or recurrent endometrial carcinoma received HMM orally at a dose of 8 mg/kg/day. Six patients (30%) showed a partial response, with a median duration of response of 3.5 months and a range of 1 to 7 months. Two patients responded to HMM as a second-line agent following previous treatment with nonhormonal chemotherapy. There were no complete responses. The major toxicities noted with HMM therapy were nausea, vomiting, and neurotoxicity. In 6 patients (30%), therapy with HMM was discontinued because of toxicity. Although HMM is active against endometrial cancer when given at a dose of 8 mg/ kg/day, it appears to have limited usefulness because toxicity precludes its prolonged administration.
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M3 - Article
C2 - 6791063
AN - SCOPUS:0019509830
SN - 0029-7844
VL - 58
SP - 361
EP - 363
JO - Obstetrics and gynecology
JF - Obstetrics and gynecology
IS - 3
ER -