High-dose carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support: excessive hepatic toxicity

Roy B. Jones; Elizabeth J. Shpall; Maureen Ross; David Coniglio; Mary Lou Affronti; William P. Peters

doi:10.1007/BF02897264

High-dose carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support: excessive hepatic toxicity

Roy B. Jones, Elizabeth J. Shpall, Maureen Ross, David Coniglio, Mary Lou Affronti, William P. Peters

Stem Cell Transplantation

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Abstract

Intensive doses of carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support were given to four patients with advanced melanoma. Three developed clinically diagnosed, severe venoocclusive liver disease, which was fatal in two cases. The dose of carboplatin (450 mg/m²) was comparable with that used in ambulatory regimens. At the doses and schedule employed, this three-drug combination produced excessive hepatic toxicity. Caution is suggested when giving carboplatin in combination with intensive doses of other chemotherapeutic agents with known hepatotoxic potential.

Original language	English (US)
Pages (from-to)	155-156
Number of pages	2
Journal	Cancer chemotherapy and pharmacology
Volume	26
Issue number	2
DOIs	https://doi.org/10.1007/BF02897264
State	Published - May 1990

ASJC Scopus subject areas

Oncology
Toxicology
Pharmacology
Cancer Research
Pharmacology (medical)

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title = "High-dose carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support: excessive hepatic toxicity",

abstract = "Intensive doses of carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support were given to four patients with advanced melanoma. Three developed clinically diagnosed, severe venoocclusive liver disease, which was fatal in two cases. The dose of carboplatin (450 mg/m2) was comparable with that used in ambulatory regimens. At the doses and schedule employed, this three-drug combination produced excessive hepatic toxicity. Caution is suggested when giving carboplatin in combination with intensive doses of other chemotherapeutic agents with known hepatotoxic potential.",

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AU - Jones, Roy B.

AU - Shpall, Elizabeth J.

AU - Ross, Maureen

AU - Coniglio, David

AU - Affronti, Mary Lou

AU - Peters, William P.

PY - 1990/5

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AB - Intensive doses of carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support were given to four patients with advanced melanoma. Three developed clinically diagnosed, severe venoocclusive liver disease, which was fatal in two cases. The dose of carboplatin (450 mg/m2) was comparable with that used in ambulatory regimens. At the doses and schedule employed, this three-drug combination produced excessive hepatic toxicity. Caution is suggested when giving carboplatin in combination with intensive doses of other chemotherapeutic agents with known hepatotoxic potential.

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High-dose carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support: excessive hepatic toxicity

Abstract

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