High dose rate gynecological applications - radiobiological considerations based on the α-β model

C. Clifton Ling; Narayan Sahoo; Steven Leibel; Lowell L. Anderson

doi:10.1016/0167-8140(92)90016-N

High dose rate gynecological applications - radiobiological considerations based on the α-β model

C. Clifton Ling, Narayan Sahoo, Steven Leibel, Lowell L. Anderson

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We compare the relative efficacy of high dose rate (HDR) and low dose rate (LDR) irradiation in gynecological implants, using formulations based on the linear-quadratic (α-β) model. We consider both acute reaction and late effect as endpoints in evaluating equivalence for HDR and LDR treatments, at Point A (as defined in the text) and at other locations. We define a therapeutic factor Γ as an index for relative efficacy, with Γ > 1 indicating a gain in substituting HDR for LDR. It is found that Γ < 1 for most clinical situations, although a modest decrease (of about 15%) in dose to critical organs for HDR would raise Γ above unity.

Original language	English (US)
Pages (from-to)	103-110
Number of pages	8
Journal	Radiotherapy and Oncology
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/0167-8140(92)90016-N
State	Published - Oct 1992
Externally published	Yes

Keywords

Brachytherapy radiobiology
High dose rate intracavitary implant
Linear-quadratic model

ASJC Scopus subject areas

Hematology
Oncology
Radiology Nuclear Medicine and imaging

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10.1016/0167-8140(92)90016-N

Cite this

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title = "High dose rate gynecological applications - radiobiological considerations based on the α-β model",

abstract = "We compare the relative efficacy of high dose rate (HDR) and low dose rate (LDR) irradiation in gynecological implants, using formulations based on the linear-quadratic (α-β) model. We consider both acute reaction and late effect as endpoints in evaluating equivalence for HDR and LDR treatments, at Point A (as defined in the text) and at other locations. We define a therapeutic factor Γ as an index for relative efficacy, with Γ > 1 indicating a gain in substituting HDR for LDR. It is found that Γ < 1 for most clinical situations, although a modest decrease (of about 15%) in dose to critical organs for HDR would raise Γ above unity.",

keywords = "Brachytherapy radiobiology, High dose rate intracavitary implant, Linear-quadratic model",

author = "Ling, {C. Clifton} and Narayan Sahoo and Steven Leibel and Anderson, {Lowell L.}",

note = "Funding Information: This work is supported in part by grants from the American Cancer Society (PDT ~ 334) and from NIH/ NCI (CA52713), Department of Health and Human Services.",

year = "1992",

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language = "English (US)",

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journal = "Radiotherapy and Oncology",

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T1 - High dose rate gynecological applications - radiobiological considerations based on the α-β model

AU - Ling, C. Clifton

AU - Sahoo, Narayan

AU - Leibel, Steven

AU - Anderson, Lowell L.

N1 - Funding Information: This work is supported in part by grants from the American Cancer Society (PDT ~ 334) and from NIH/ NCI (CA52713), Department of Health and Human Services.

PY - 1992/10

Y1 - 1992/10

N2 - We compare the relative efficacy of high dose rate (HDR) and low dose rate (LDR) irradiation in gynecological implants, using formulations based on the linear-quadratic (α-β) model. We consider both acute reaction and late effect as endpoints in evaluating equivalence for HDR and LDR treatments, at Point A (as defined in the text) and at other locations. We define a therapeutic factor Γ as an index for relative efficacy, with Γ > 1 indicating a gain in substituting HDR for LDR. It is found that Γ < 1 for most clinical situations, although a modest decrease (of about 15%) in dose to critical organs for HDR would raise Γ above unity.

AB - We compare the relative efficacy of high dose rate (HDR) and low dose rate (LDR) irradiation in gynecological implants, using formulations based on the linear-quadratic (α-β) model. We consider both acute reaction and late effect as endpoints in evaluating equivalence for HDR and LDR treatments, at Point A (as defined in the text) and at other locations. We define a therapeutic factor Γ as an index for relative efficacy, with Γ > 1 indicating a gain in substituting HDR for LDR. It is found that Γ < 1 for most clinical situations, although a modest decrease (of about 15%) in dose to critical organs for HDR would raise Γ above unity.

KW - Brachytherapy radiobiology

KW - High dose rate intracavitary implant

KW - Linear-quadratic model

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IS - 2

ER -

High dose rate gynecological applications - radiobiological considerations based on the α-β model

Abstract

Keywords

ASJC Scopus subject areas

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