High-Intensity Interval Training Is Feasible in Women at High Risk for Breast Cancer

Adriana M. Coletta; Abenaa M. Brewster; Minxing Chen; Yisheng Li; Therese B. Bevers; Karen Basen-Engquist; Susan C. Gilchrist

doi:10.1249/MSS.0000000000002048

High-Intensity Interval Training Is Feasible in Women at High Risk for Breast Cancer

Adriana M. Coletta, Abenaa M. Brewster, Minxing Chen, Yisheng Li, Therese B. Bevers, Karen Basen-Engquist, Susan C. Gilchrist

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

COLETTA, A. M., A. M. BREWSTER, M. CHEN, Y. LI, T. B. BEVERS, K. BASEN-ENGQUIST, and S. C. GILCHRIST. High-Intensity Interval Training Is Feasible in Women at High Risk for Breast Cancer. Med. Sci. Sports Exerc., Vol. 51, No. 11, pp. 2193–2200, 2019. Purpose: This trial aimed to demonstrate the feasibility of high-intensity interval training (HIIT) in postmenopausal, overweight/obese women at high risk of invasive breast cancer and to explore HIIT on changes in cardiorespiratory fitness (CRF), body weight, and body mass index (BMI) compared with moderate-intensity continuous training (MICT) and usual care (UC). Methods: Forty-four women were randomized to HIIT, MICT, or UC for a 12-wk, thrice weekly, supervised exercise intervention. HIIT included a 5-min warm-up at 50%–70% HR_peak, four cycles of 4 min at 90%–100% HR_peak, followed by 3 min at 50%–70% HR_peak. MICT consisted of 41 min at 60%–70% HR_peak. Feasibility was assessed by consent, adherence, compliance, and retention rates. CRF, body weight, and BMI were measured at baseline and end of study. Repeated-measures linear mixed models were used to assess within- and between-group differences. Results: Average age was 63.9 ± 8.8 yr. BMI was 30.9 ± 5.7 kg·m⁻². Participants completed 90% and 89% of HIIT and MICT workouts, respectively, with 100% compliance to the exercise prescriptions. No serious adverse events were reported. Compared with MICT and UC, HIIT exhibited improvements in change in treadmill time (101 s greater than MICT, and 125 s greater than UC, respectively, P < 0.001). Compared with UC, HIIT exhibited improvement in changes in absolute and relative VO_2peak (a 0.15-L·min⁻¹ increase, P = 0.005, and a 2.3-mL·kg⁻¹min⁻¹ increase, P = 0.004). There were no significant differences between groups for body weight or BMI (P > 0.05). Conclusions: HIIT is feasible, safe, and seems to promote greater improvements in CRF compared with MICT and UC in women at high risk for breast cancer.

Original language	English (US)
Pages (from-to)	2193-2200
Number of pages	8
Journal	Medicine and science in sports and exercise
Volume	51
Issue number	11
DOIs	https://doi.org/10.1249/MSS.0000000000002048
State	Published - Nov 1 2019

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

MD Anderson CCSG core facilities

Assessment, Intervention, and Measurement
Biostatistics Resource Group

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10.1249/MSS.0000000000002048

Cite this

@article{41ef1b17640047558dc3c4ad26990ef9,

title = "High-Intensity Interval Training Is Feasible in Women at High Risk for Breast Cancer",

abstract = "COLETTA, A. M., A. M. BREWSTER, M. CHEN, Y. LI, T. B. BEVERS, K. BASEN-ENGQUIST, and S. C. GILCHRIST. High-Intensity Interval Training Is Feasible in Women at High Risk for Breast Cancer. Med. Sci. Sports Exerc., Vol. 51, No. 11, pp. 2193–2200, 2019. Purpose: This trial aimed to demonstrate the feasibility of high-intensity interval training (HIIT) in postmenopausal, overweight/obese women at high risk of invasive breast cancer and to explore HIIT on changes in cardiorespiratory fitness (CRF), body weight, and body mass index (BMI) compared with moderate-intensity continuous training (MICT) and usual care (UC). Methods: Forty-four women were randomized to HIIT, MICT, or UC for a 12-wk, thrice weekly, supervised exercise intervention. HIIT included a 5-min warm-up at 50%–70% HRpeak, four cycles of 4 min at 90%–100% HRpeak, followed by 3 min at 50%–70% HRpeak. MICT consisted of 41 min at 60%–70% HRpeak. Feasibility was assessed by consent, adherence, compliance, and retention rates. CRF, body weight, and BMI were measured at baseline and end of study. Repeated-measures linear mixed models were used to assess within- and between-group differences. Results: Average age was 63.9 ± 8.8 yr. BMI was 30.9 ± 5.7 kg·m−2. Participants completed 90% and 89% of HIIT and MICT workouts, respectively, with 100% compliance to the exercise prescriptions. No serious adverse events were reported. Compared with MICT and UC, HIIT exhibited improvements in change in treadmill time (101 s greater than MICT, and 125 s greater than UC, respectively, P < 0.001). Compared with UC, HIIT exhibited improvement in changes in absolute and relative VO2peak (a 0.15-L·min−1 increase, P = 0.005, and a 2.3-mL·kg−1min−1 increase, P = 0.004). There were no significant differences between groups for body weight or BMI (P > 0.05). Conclusions: HIIT is feasible, safe, and seems to promote greater improvements in CRF compared with MICT and UC in women at high risk for breast cancer.",

author = "Coletta, {Adriana M.} and Brewster, {Abenaa M.} and Minxing Chen and Yisheng Li and Bevers, {Therese B.} and Karen Basen-Engquist and Gilchrist, {Susan C.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s). Published by Wolters Kluwer Health, Inc.",

year = "2019",

month = nov,

day = "1",

doi = "10.1249/MSS.0000000000002048",

language = "English (US)",

volume = "51",

pages = "2193--2200",

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T1 - High-Intensity Interval Training Is Feasible in Women at High Risk for Breast Cancer

AU - Coletta, Adriana M.

AU - Brewster, Abenaa M.

AU - Chen, Minxing

AU - Li, Yisheng

AU - Bevers, Therese B.

AU - Basen-Engquist, Karen

AU - Gilchrist, Susan C.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - COLETTA, A. M., A. M. BREWSTER, M. CHEN, Y. LI, T. B. BEVERS, K. BASEN-ENGQUIST, and S. C. GILCHRIST. High-Intensity Interval Training Is Feasible in Women at High Risk for Breast Cancer. Med. Sci. Sports Exerc., Vol. 51, No. 11, pp. 2193–2200, 2019. Purpose: This trial aimed to demonstrate the feasibility of high-intensity interval training (HIIT) in postmenopausal, overweight/obese women at high risk of invasive breast cancer and to explore HIIT on changes in cardiorespiratory fitness (CRF), body weight, and body mass index (BMI) compared with moderate-intensity continuous training (MICT) and usual care (UC). Methods: Forty-four women were randomized to HIIT, MICT, or UC for a 12-wk, thrice weekly, supervised exercise intervention. HIIT included a 5-min warm-up at 50%–70% HRpeak, four cycles of 4 min at 90%–100% HRpeak, followed by 3 min at 50%–70% HRpeak. MICT consisted of 41 min at 60%–70% HRpeak. Feasibility was assessed by consent, adherence, compliance, and retention rates. CRF, body weight, and BMI were measured at baseline and end of study. Repeated-measures linear mixed models were used to assess within- and between-group differences. Results: Average age was 63.9 ± 8.8 yr. BMI was 30.9 ± 5.7 kg·m−2. Participants completed 90% and 89% of HIIT and MICT workouts, respectively, with 100% compliance to the exercise prescriptions. No serious adverse events were reported. Compared with MICT and UC, HIIT exhibited improvements in change in treadmill time (101 s greater than MICT, and 125 s greater than UC, respectively, P < 0.001). Compared with UC, HIIT exhibited improvement in changes in absolute and relative VO2peak (a 0.15-L·min−1 increase, P = 0.005, and a 2.3-mL·kg−1min−1 increase, P = 0.004). There were no significant differences between groups for body weight or BMI (P > 0.05). Conclusions: HIIT is feasible, safe, and seems to promote greater improvements in CRF compared with MICT and UC in women at high risk for breast cancer.

AB - COLETTA, A. M., A. M. BREWSTER, M. CHEN, Y. LI, T. B. BEVERS, K. BASEN-ENGQUIST, and S. C. GILCHRIST. High-Intensity Interval Training Is Feasible in Women at High Risk for Breast Cancer. Med. Sci. Sports Exerc., Vol. 51, No. 11, pp. 2193–2200, 2019. Purpose: This trial aimed to demonstrate the feasibility of high-intensity interval training (HIIT) in postmenopausal, overweight/obese women at high risk of invasive breast cancer and to explore HIIT on changes in cardiorespiratory fitness (CRF), body weight, and body mass index (BMI) compared with moderate-intensity continuous training (MICT) and usual care (UC). Methods: Forty-four women were randomized to HIIT, MICT, or UC for a 12-wk, thrice weekly, supervised exercise intervention. HIIT included a 5-min warm-up at 50%–70% HRpeak, four cycles of 4 min at 90%–100% HRpeak, followed by 3 min at 50%–70% HRpeak. MICT consisted of 41 min at 60%–70% HRpeak. Feasibility was assessed by consent, adherence, compliance, and retention rates. CRF, body weight, and BMI were measured at baseline and end of study. Repeated-measures linear mixed models were used to assess within- and between-group differences. Results: Average age was 63.9 ± 8.8 yr. BMI was 30.9 ± 5.7 kg·m−2. Participants completed 90% and 89% of HIIT and MICT workouts, respectively, with 100% compliance to the exercise prescriptions. No serious adverse events were reported. Compared with MICT and UC, HIIT exhibited improvements in change in treadmill time (101 s greater than MICT, and 125 s greater than UC, respectively, P < 0.001). Compared with UC, HIIT exhibited improvement in changes in absolute and relative VO2peak (a 0.15-L·min−1 increase, P = 0.005, and a 2.3-mL·kg−1min−1 increase, P = 0.004). There were no significant differences between groups for body weight or BMI (P > 0.05). Conclusions: HIIT is feasible, safe, and seems to promote greater improvements in CRF compared with MICT and UC in women at high risk for breast cancer.

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High-Intensity Interval Training Is Feasible in Women at High Risk for Breast Cancer

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MD Anderson CCSG core facilities

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