High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma

Michael Green; Maher K Gandhi; Emily Camilleri; Paula Marlton; Rod Lea; Lyn Griffiths

doi:10.1016/j.leukres.2008.09.007

High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma

Michael Green, Maher K Gandhi, Emily Camilleri, Paula Marlton, Rod Lea, Lyn Griffiths

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The t(14;18)(q21;q34) BCL2 translocation is a common genetic alteration in follicular and diffuse large B-cell lymphoma. However, it is not invariably associated with BCL2 gene overexpression due to undefined mechanisms that regulate expression from the proximal immunoglobulin heavy-chain (IgH) promoter. The BACH2 transcriptional repressor is able to modulate activity of this promoter. Here we have shown that, in tumor samples with BCL2 translocation, those with high levels of BACH2 had significantly lower BCL2 transcript abundance compared to those with low levels of BACH2. This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation.

Original language	English (US)
Pages (from-to)	731-4
Number of pages	4
Journal	Leukemia Research
Volume	33
Issue number	5
DOIs	https://doi.org/10.1016/j.leukres.2008.09.007
State	Published - May 2009
Externally published	Yes

Keywords

Base Sequence
Basic-Leucine Zipper Transcription Factors/genetics
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
DNA Primers
Humans
Immunoglobulin Heavy Chains/genetics
Lymphoma, Non-Hodgkin/genetics
Polymerase Chain Reaction
Promoter Regions, Genetic
Proto-Oncogene Proteins c-bcl-2/genetics
RNA, Messenger/genetics
Translocation, Genetic

Access to Document

10.1016/j.leukres.2008.09.007

Cite this

@article{a244fd308b8149b8b8cdd3ac17ed1a5b,

title = "High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma",

abstract = "The t(14;18)(q21;q34) BCL2 translocation is a common genetic alteration in follicular and diffuse large B-cell lymphoma. However, it is not invariably associated with BCL2 gene overexpression due to undefined mechanisms that regulate expression from the proximal immunoglobulin heavy-chain (IgH) promoter. The BACH2 transcriptional repressor is able to modulate activity of this promoter. Here we have shown that, in tumor samples with BCL2 translocation, those with high levels of BACH2 had significantly lower BCL2 transcript abundance compared to those with low levels of BACH2. This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation.",

keywords = "Base Sequence, Basic-Leucine Zipper Transcription Factors/genetics, Chromosomes, Human, Pair 14, Chromosomes, Human, Pair 18, DNA Primers, Humans, Immunoglobulin Heavy Chains/genetics, Lymphoma, Non-Hodgkin/genetics, Polymerase Chain Reaction, Promoter Regions, Genetic, Proto-Oncogene Proteins c-bcl-2/genetics, RNA, Messenger/genetics, Translocation, Genetic",

author = "Michael Green and Gandhi, {Maher K} and Emily Camilleri and Paula Marlton and Rod Lea and Lyn Griffiths",

year = "2009",

month = may,

doi = "10.1016/j.leukres.2008.09.007",

language = "English (US)",

volume = "33",

pages = "731--4",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

number = "5",

}

TY - JOUR

T1 - High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma

AU - Green, Michael

AU - Gandhi, Maher K

AU - Camilleri, Emily

AU - Marlton, Paula

AU - Lea, Rod

AU - Griffiths, Lyn

PY - 2009/5

Y1 - 2009/5

N2 - The t(14;18)(q21;q34) BCL2 translocation is a common genetic alteration in follicular and diffuse large B-cell lymphoma. However, it is not invariably associated with BCL2 gene overexpression due to undefined mechanisms that regulate expression from the proximal immunoglobulin heavy-chain (IgH) promoter. The BACH2 transcriptional repressor is able to modulate activity of this promoter. Here we have shown that, in tumor samples with BCL2 translocation, those with high levels of BACH2 had significantly lower BCL2 transcript abundance compared to those with low levels of BACH2. This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation.

AB - The t(14;18)(q21;q34) BCL2 translocation is a common genetic alteration in follicular and diffuse large B-cell lymphoma. However, it is not invariably associated with BCL2 gene overexpression due to undefined mechanisms that regulate expression from the proximal immunoglobulin heavy-chain (IgH) promoter. The BACH2 transcriptional repressor is able to modulate activity of this promoter. Here we have shown that, in tumor samples with BCL2 translocation, those with high levels of BACH2 had significantly lower BCL2 transcript abundance compared to those with low levels of BACH2. This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation.

KW - Base Sequence

KW - Basic-Leucine Zipper Transcription Factors/genetics

KW - Chromosomes, Human, Pair 14

KW - Chromosomes, Human, Pair 18

KW - DNA Primers

KW - Humans

KW - Immunoglobulin Heavy Chains/genetics

KW - Lymphoma, Non-Hodgkin/genetics

KW - Polymerase Chain Reaction

KW - Promoter Regions, Genetic

KW - Proto-Oncogene Proteins c-bcl-2/genetics

KW - RNA, Messenger/genetics

KW - Translocation, Genetic

U2 - 10.1016/j.leukres.2008.09.007

DO - 10.1016/j.leukres.2008.09.007

M3 - Article

C2 - 18929412

SN - 0145-2126

VL - 33

SP - 731

EP - 734

JO - Leukemia Research

JF - Leukemia Research

IS - 5

ER -

High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma

Abstract

Keywords

Access to Document

Fingerprint

Cite this