TY - JOUR
T1 - High-risk metastatic gestational trophoblastic disease
T2 - Further stratification into two clinical entities
AU - Gordon, Alan N.
AU - Gershenson, David M.
AU - Copeland, Larry J.
AU - Stringer, C. Allen
AU - Morris, Mitchell
AU - Wharton, J. Taylor
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1989/7
Y1 - 1989/7
N2 - Forty-two of sixty-seven patients (62.7%) treated for high-risk metastatic trophoblastic disease achieved and maintained complete remissions. The survival rate was significantly improved in those patients with scores lower than 8 according to a modification of the World Health Organization (WHO) prognostic scoring system. A low score was associated with a higher probability of response to single-agent therapy, although the difference was not statistically significant. The score, however, was significantly associated with response to multiagent chemotherapy with methotrexate, actinomycin D, and cyclophosphamide (P = 0.0004). Therefore, future trials of new combinations of chemotherapy in high-risk patients should be stratified according to the patients' prognostic scores.
AB - Forty-two of sixty-seven patients (62.7%) treated for high-risk metastatic trophoblastic disease achieved and maintained complete remissions. The survival rate was significantly improved in those patients with scores lower than 8 according to a modification of the World Health Organization (WHO) prognostic scoring system. A low score was associated with a higher probability of response to single-agent therapy, although the difference was not statistically significant. The score, however, was significantly associated with response to multiagent chemotherapy with methotrexate, actinomycin D, and cyclophosphamide (P = 0.0004). Therefore, future trials of new combinations of chemotherapy in high-risk patients should be stratified according to the patients' prognostic scores.
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U2 - 10.1016/0090-8258(89)90106-6
DO - 10.1016/0090-8258(89)90106-6
M3 - Article
C2 - 2544490
AN - SCOPUS:0024319013
SN - 0090-8258
VL - 34
SP - 54
EP - 56
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 1
ER -