TY - JOUR
T1 - High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases
AU - Gao, Mamie
AU - Zhong, Allen
AU - Patel, Neil
AU - Alur, Chiraag
AU - Vyas, Dinesh
N1 - Publisher Copyright:
© 2017 Baishideng Publishing Group Inc. All rights reserved.
PY - 2017/4/28
Y1 - 2017/4/28
N2 - RNA sequencing is the use of high throughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differential expression of genes (DEG's), mutated genes, fusion genes, and gene isoforms in disease states. RNA sequencing has been used in the investigation of several colorectal diseases such as colorectal cancer, inflammatory bowel disease (ulcerative colitis and Crohn's disease), and irritable bowel syndrome.
AB - RNA sequencing is the use of high throughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differential expression of genes (DEG's), mutated genes, fusion genes, and gene isoforms in disease states. RNA sequencing has been used in the investigation of several colorectal diseases such as colorectal cancer, inflammatory bowel disease (ulcerative colitis and Crohn's disease), and irritable bowel syndrome.
KW - Colon
KW - Colon cancer
KW - High throughput
KW - Next generation sequencing
KW - RNA sequencing
KW - Transcriptome
UR - http://www.scopus.com/inward/record.url?scp=85018949484&partnerID=8YFLogxK
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U2 - 10.3748/wjg.v23.i16.2819
DO - 10.3748/wjg.v23.i16.2819
M3 - Review article
C2 - 28522900
AN - SCOPUS:85018949484
SN - 1007-9327
VL - 23
SP - 2819
EP - 2825
JO - World journal of gastroenterology
JF - World journal of gastroenterology
IS - 16
ER -