High‐dose chemotherapy and unpurged autologous bone marrow transplantation for acute leukemia in second or subsequent remission

Jorge A. Spinolo; Karel A. Dicke; Leonard J. Horwitz; Sundar Jagannath; Kenneth McCredie; Elihu Estey; Hagop Kantarjian; Axel R. Zander; Michael Keating; Gary Spitzer

doi:10.1002/1097-0142(19900815)66:4<619::AID-CNCR2820660403>3.0.CO;2-Z

High‐dose chemotherapy and unpurged autologous bone marrow transplantation for acute leukemia in second or subsequent remission

Jorge A. Spinolo, Karel A. Dicke, Leonard J. Horwitz, Sundar Jagannath, Kenneth McCredie, Elihu Estey, Hagop Kantarjian, Axel R. Zander, Michael Keating, Gary Spitzer

Leukemia

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7 Scopus citations

Abstract

The authors administered high‐dose chemotherapy with cyclophosphamide, BCNU (carmustine) and VP‐16 (etoposide) plus autologous bone marrow transplantation (ABMT) to 22 adult patients with relapsed acute leukemia in second or subsequent remission. The marrow was not treated ex vivo. The long‐term, disease‐free survival rate was 14%. Comparison of results with other treatments can be difficult because of patient selection biases. The concept of inversion (achievement of a longer remission with salvage therapy than with prior treatments) is proposed to compare treatment results. Three patients remain in complete remission beyond 4 years, with inversions. More intensive cytoreductive regimens will be needed to improve results.

Original language	English (US)
Pages (from-to)	619-626
Number of pages	8
Journal	Cancer
Volume	66
Issue number	4
DOIs	https://doi.org/10.1002/1097-0142(19900815)66:4<619::AID-CNCR2820660403>3.0.CO;2-Z
State	Published - Aug 15 1990

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19900815)66:4<619::AID-CNCR2820660403>3.0.CO;2-Z

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Spinolo, J. A., Dicke, K. A., Horwitz, L. J., Jagannath, S., McCredie, K., Estey, E., Kantarjian, H., Zander, A. R., Keating, M., & Spitzer, G. (1990). High‐dose chemotherapy and unpurged autologous bone marrow transplantation for acute leukemia in second or subsequent remission. Cancer, 66(4), 619-626. https://doi.org/10.1002/1097-0142(19900815)66:4<619::AID-CNCR2820660403>3.0.CO;2-Z

Spinolo, JA, Dicke, KA, Horwitz, LJ, Jagannath, S, McCredie, K, Estey, E, Kantarjian, H, Zander, AR, Keating, M & Spitzer, G 1990, 'High‐dose chemotherapy and unpurged autologous bone marrow transplantation for acute leukemia in second or subsequent remission', Cancer, vol. 66, no. 4, pp. 619-626. https://doi.org/10.1002/1097-0142(19900815)66:4<619::AID-CNCR2820660403>3.0.CO;2-Z

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abstract = "The authors administered high‐dose chemotherapy with cyclophosphamide, BCNU (carmustine) and VP‐16 (etoposide) plus autologous bone marrow transplantation (ABMT) to 22 adult patients with relapsed acute leukemia in second or subsequent remission. The marrow was not treated ex vivo. The long‐term, disease‐free survival rate was 14%. Comparison of results with other treatments can be difficult because of patient selection biases. The concept of inversion (achievement of a longer remission with salvage therapy than with prior treatments) is proposed to compare treatment results. Three patients remain in complete remission beyond 4 years, with inversions. More intensive cytoreductive regimens will be needed to improve results.",

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AU - Spinolo, Jorge A.

AU - Dicke, Karel A.

AU - Horwitz, Leonard J.

AU - Jagannath, Sundar

AU - McCredie, Kenneth

AU - Estey, Elihu

AU - Kantarjian, Hagop

AU - Zander, Axel R.

AU - Keating, Michael

AU - Spitzer, Gary

PY - 1990/8/15

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AB - The authors administered high‐dose chemotherapy with cyclophosphamide, BCNU (carmustine) and VP‐16 (etoposide) plus autologous bone marrow transplantation (ABMT) to 22 adult patients with relapsed acute leukemia in second or subsequent remission. The marrow was not treated ex vivo. The long‐term, disease‐free survival rate was 14%. Comparison of results with other treatments can be difficult because of patient selection biases. The concept of inversion (achievement of a longer remission with salvage therapy than with prior treatments) is proposed to compare treatment results. Three patients remain in complete remission beyond 4 years, with inversions. More intensive cytoreductive regimens will be needed to improve results.

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High‐dose chemotherapy and unpurged autologous bone marrow transplantation for acute leukemia in second or subsequent remission

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