TY - JOUR
T1 - Highlighting transcribed ultraconserved regions in human diseases
AU - Pereira Zambalde, Erika
AU - Mathias, Carolina
AU - Rodrigues, Ana Carolina
AU - de Souza Fonseca Ribeiro, Enilze M.
AU - Fiori Gradia, Daniela
AU - Calin, George A.
AU - Carvalho de Oliveira, Jaqueline
N1 - Funding Information:
The authors would like to thank the Academic Publishing Advisory Center (Centro de Assessoria de Publicação, CAPA—www.capa.ufpr.br) of the Federal University of Paraná for assistance with English language translation and editing.
Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Ultraconserved regions (UCRs) are 481 DNA segments longer than 200 bp in length that are completely conserved among human, mouse, and rat and, extremely conserved across disparate taxa. More than 90% of UCRs are transcribed (T-UCRs) in normal tissues, but most of them remain uncharacterized. In addition, it was demonstrated that T-UCRs have a tissue-specific expression, and a differential expression profile between tumors and other diseases, which suggests that most of T-UCRs may have an important role in cell processes. However, there is little information about T-UCR characterization or about their molecular mechanisms of action. Taking this into account, in this study, we aim to summarize deregulated T-UCRs in human diseases, emphasizing the ones with stronger functional evidences that are associated with important cell pathways and have a detailed molecular characterization. This article is characterized under: RNA in Disease and Development > RNA in Disease Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs.
AB - Ultraconserved regions (UCRs) are 481 DNA segments longer than 200 bp in length that are completely conserved among human, mouse, and rat and, extremely conserved across disparate taxa. More than 90% of UCRs are transcribed (T-UCRs) in normal tissues, but most of them remain uncharacterized. In addition, it was demonstrated that T-UCRs have a tissue-specific expression, and a differential expression profile between tumors and other diseases, which suggests that most of T-UCRs may have an important role in cell processes. However, there is little information about T-UCR characterization or about their molecular mechanisms of action. Taking this into account, in this study, we aim to summarize deregulated T-UCRs in human diseases, emphasizing the ones with stronger functional evidences that are associated with important cell pathways and have a detailed molecular characterization. This article is characterized under: RNA in Disease and Development > RNA in Disease Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs.
KW - T-UCR
KW - cancer
KW - diseases
KW - long noncoding RNA
KW - transcribed ultraconserved regions
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U2 - 10.1002/wrna.1567
DO - 10.1002/wrna.1567
M3 - Review article
C2 - 31489780
AN - SCOPUS:85071848510
SN - 1757-7004
VL - 11
JO - Wiley Interdisciplinary Reviews: RNA
JF - Wiley Interdisciplinary Reviews: RNA
IS - 2
M1 - e1567
ER -