Abstract
Blue nevi are a heterogeneous group of dermal melanocytic proliferations that share a common clinical appearance but remain controversial in their histopathologic and biologic distinction. While common blue nevi and cellular blue nevi are well-defined entities that are classified without significant controversy, the distinction between atypical cellular blue nevi and blue nevus-like melanoma remains diagnostically challenging. We report a case of a 46-year-old female with recurrent blue nevus-like melanoma of the scalp with liver metastases; mutational analysis showed GNA11 Q209L and BAP1 Q393 mutations. To our knowledge, this is the first case of blue nevus-like melanoma with GNA11 and BAP1 mutations. These particular mutations and the predilection for liver metastases in our patient's case underscore a fundamental biological relationship between blue nevi and uveal melanoma and suggest the two entities may prove amenable to similar diagnostic and prognostic testing and targeted therapies.
Original language | English (US) |
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Pages (from-to) | 776-780 |
Number of pages | 5 |
Journal | Journal of cutaneous pathology |
Volume | 43 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2016 |
Keywords
- BAP1
- GNA11
- GNAQ
- blue nevus
- melanoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Dermatology