Histopathological differences of myotonic dystrophy type 1 (DM1) and PROMM/DM2

A. Vihola; G. Bassez; G. Meola; S. Zhang; H. Haapasalo; A. Paetau; E. Mancinelli; A. Rouche; J. Y. Hogrel; P. Laforêt; T. Maisonobe; J. F. Pellissier; R. Krahe; B. Eymard; Bjarne Udd

doi:10.1212/01.WNL.0000065898.61358.09

Histopathological differences of myotonic dystrophy type 1 (DM1) and PROMM/DM2

A. Vihola, G. Bassez, G. Meola, S. Zhang, H. Haapasalo, A. Paetau, E. Mancinelli, A. Rouche, J. Y. Hogrel, P. Laforêt, T. Maisonobe, J. F. Pellissier, R. Krahe, B. Eymard, Bjarne Udd

Genetics

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

Muscle biopsy findings in DM2 have been reported to be similar to those in DM1. The authors used myosin heavy chain immunohistochemistry and enzyme histochemistry for fiber type differentiation on muscle biopsies. Their results show that DM2 patients display a subpopulation of type 2 nuclear clump and other very small fibers and, hence, preferential type 2 fiber atrophy in contrast to type 1 fiber atrophy in DM1 patients.

Original language	English (US)
Pages (from-to)	1854-1857
Number of pages	4
Journal	Neurology
Volume	60
Issue number	11
DOIs	https://doi.org/10.1212/01.WNL.0000065898.61358.09
State	Published - Jun 10 2003

ASJC Scopus subject areas

Clinical Neurology

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10.1212/01.WNL.0000065898.61358.09

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title = "Histopathological differences of myotonic dystrophy type 1 (DM1) and PROMM/DM2",

abstract = "Muscle biopsy findings in DM2 have been reported to be similar to those in DM1. The authors used myosin heavy chain immunohistochemistry and enzyme histochemistry for fiber type differentiation on muscle biopsies. Their results show that DM2 patients display a subpopulation of type 2 nuclear clump and other very small fibers and, hence, preferential type 2 fiber atrophy in contrast to type 1 fiber atrophy in DM1 patients.",

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T1 - Histopathological differences of myotonic dystrophy type 1 (DM1) and PROMM/DM2

AU - Vihola, A.

AU - Bassez, G.

AU - Meola, G.

AU - Zhang, S.

AU - Haapasalo, H.

AU - Paetau, A.

AU - Mancinelli, E.

AU - Rouche, A.

AU - Hogrel, J. Y.

AU - Laforêt, P.

AU - Maisonobe, T.

AU - Pellissier, J. F.

AU - Krahe, R.

AU - Eymard, B.

AU - Udd, Bjarne

PY - 2003/6/10

Y1 - 2003/6/10

N2 - Muscle biopsy findings in DM2 have been reported to be similar to those in DM1. The authors used myosin heavy chain immunohistochemistry and enzyme histochemistry for fiber type differentiation on muscle biopsies. Their results show that DM2 patients display a subpopulation of type 2 nuclear clump and other very small fibers and, hence, preferential type 2 fiber atrophy in contrast to type 1 fiber atrophy in DM1 patients.

AB - Muscle biopsy findings in DM2 have been reported to be similar to those in DM1. The authors used myosin heavy chain immunohistochemistry and enzyme histochemistry for fiber type differentiation on muscle biopsies. Their results show that DM2 patients display a subpopulation of type 2 nuclear clump and other very small fibers and, hence, preferential type 2 fiber atrophy in contrast to type 1 fiber atrophy in DM1 patients.

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ER -

Histopathological differences of myotonic dystrophy type 1 (DM1) and PROMM/DM2

Abstract

ASJC Scopus subject areas

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