HLA and ethnic associations among systemic sclerosis patients with anticentromere antibodies

Penelope A. Morel; Huan J. Chang; John W. Wilson; Claudia Conte; Dewayne Falkner; David J. Tweardy; Thomas A. Medsger

doi:10.1016/0198-8859(94)00078-5

HLA and ethnic associations among systemic sclerosis patients with anticentromere antibodies

Penelope A. Morel, Huan J. Chang, John W. Wilson, Claudia Conte, Dewayne Falkner, David J. Tweardy, Thomas A. Medsger

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

SSc with ACAs is characterized by limited cutaneous involvement and, in most patients, a mild protracted course. We have studied 104 SSc patients, 47 with ACAs and 57 who were negative for both ACAs and anti-topo I antibodies, for HLA-DR and -DQ associations using DNA typing techniques. Normal controls consisted of 181 healthy individuals. A significant association was observed in the ACA-positive patients with DQB1-0501 (p = 0.001, RR 2.6). There was also a significant decrease in the frequency of DQB1-0201 (p = 0.01, RR 0.33). In addition, the ACA-positive SSc patients were significantly different ethnically from both the other SSc patients and the normal controls (p = 0.004). When patients were stratified according to their ethnic origin and the analysis of HLA associations was repeated, the HLA associations persisted. These results strongly suggest that the development of SSc with ACAs is associated with particular DQB1 alleles, and also that ethnic origin plays a role in disease susceptibility.

Original language	English (US)
Pages (from-to)	35-42
Number of pages	8
Journal	Human Immunology
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/0198-8859(94)00078-5
State	Published - Jan 1995
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0198-8859(94)00078-5

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@article{affd8dc608be4a37a3dd22186d5e7d0b,

title = "HLA and ethnic associations among systemic sclerosis patients with anticentromere antibodies",

abstract = "SSc with ACAs is characterized by limited cutaneous involvement and, in most patients, a mild protracted course. We have studied 104 SSc patients, 47 with ACAs and 57 who were negative for both ACAs and anti-topo I antibodies, for HLA-DR and -DQ associations using DNA typing techniques. Normal controls consisted of 181 healthy individuals. A significant association was observed in the ACA-positive patients with DQB1-0501 (p = 0.001, RR 2.6). There was also a significant decrease in the frequency of DQB1-0201 (p = 0.01, RR 0.33). In addition, the ACA-positive SSc patients were significantly different ethnically from both the other SSc patients and the normal controls (p = 0.004). When patients were stratified according to their ethnic origin and the analysis of HLA associations was repeated, the HLA associations persisted. These results strongly suggest that the development of SSc with ACAs is associated with particular DQB1 alleles, and also that ethnic origin plays a role in disease susceptibility.",

author = "Morel, {Penelope A.} and Chang, {Huan J.} and Wilson, {John W.} and Claudia Conte and Dewayne Falkner and Tweardy, {David J.} and Medsger, {Thomas A.}",

note = "Funding Information: We thank Carol Blair, RN, and Gigi Allias, RN, for assis-tancei n collectingb lood samplesa nd clinical and ethnico rigin informationf rom the patients,a nd Noellene Zabo and Noreen Fertig for expertt echnicala ssistanceT. his work wass upported by the SclerodermaF ederation,N ew York, NY; the Arthritis Foundation, Western Pennsylvania Chapter (ShoemakerF und) Pittsburgh, PA; the RGK Foundation, Austin, TX; the National Institutes of Health grant AM21393 to ARAMIS (Arthritis, Rheumatism, and Aging Medical Information System) and contract (NO1 AI 15115) and NIH Core grant 2P30 CA47904; and the University of Pittsburgh General Clinical Research Center (5MOl-RR00056).",

year = "1995",

month = jan,

doi = "10.1016/0198-8859(94)00078-5",

language = "English (US)",

volume = "42",

pages = "35--42",

journal = "Human Immunology",

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TY - JOUR

T1 - HLA and ethnic associations among systemic sclerosis patients with anticentromere antibodies

AU - Morel, Penelope A.

AU - Chang, Huan J.

AU - Wilson, John W.

AU - Conte, Claudia

AU - Falkner, Dewayne

AU - Tweardy, David J.

AU - Medsger, Thomas A.

N1 - Funding Information: We thank Carol Blair, RN, and Gigi Allias, RN, for assis-tancei n collectingb lood samplesa nd clinical and ethnico rigin informationf rom the patients,a nd Noellene Zabo and Noreen Fertig for expertt echnicala ssistanceT. his work wass upported by the SclerodermaF ederation,N ew York, NY; the Arthritis Foundation, Western Pennsylvania Chapter (ShoemakerF und) Pittsburgh, PA; the RGK Foundation, Austin, TX; the National Institutes of Health grant AM21393 to ARAMIS (Arthritis, Rheumatism, and Aging Medical Information System) and contract (NO1 AI 15115) and NIH Core grant 2P30 CA47904; and the University of Pittsburgh General Clinical Research Center (5MOl-RR00056).

PY - 1995/1

Y1 - 1995/1

N2 - SSc with ACAs is characterized by limited cutaneous involvement and, in most patients, a mild protracted course. We have studied 104 SSc patients, 47 with ACAs and 57 who were negative for both ACAs and anti-topo I antibodies, for HLA-DR and -DQ associations using DNA typing techniques. Normal controls consisted of 181 healthy individuals. A significant association was observed in the ACA-positive patients with DQB1-0501 (p = 0.001, RR 2.6). There was also a significant decrease in the frequency of DQB1-0201 (p = 0.01, RR 0.33). In addition, the ACA-positive SSc patients were significantly different ethnically from both the other SSc patients and the normal controls (p = 0.004). When patients were stratified according to their ethnic origin and the analysis of HLA associations was repeated, the HLA associations persisted. These results strongly suggest that the development of SSc with ACAs is associated with particular DQB1 alleles, and also that ethnic origin plays a role in disease susceptibility.

AB - SSc with ACAs is characterized by limited cutaneous involvement and, in most patients, a mild protracted course. We have studied 104 SSc patients, 47 with ACAs and 57 who were negative for both ACAs and anti-topo I antibodies, for HLA-DR and -DQ associations using DNA typing techniques. Normal controls consisted of 181 healthy individuals. A significant association was observed in the ACA-positive patients with DQB1-0501 (p = 0.001, RR 2.6). There was also a significant decrease in the frequency of DQB1-0201 (p = 0.01, RR 0.33). In addition, the ACA-positive SSc patients were significantly different ethnically from both the other SSc patients and the normal controls (p = 0.004). When patients were stratified according to their ethnic origin and the analysis of HLA associations was repeated, the HLA associations persisted. These results strongly suggest that the development of SSc with ACAs is associated with particular DQB1 alleles, and also that ethnic origin plays a role in disease susceptibility.

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HLA and ethnic associations among systemic sclerosis patients with anticentromere antibodies

Abstract

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