@article{a875c4aa5c2b4b7ebd0e37bff8ebe3b0,
title = "Home-based exercise during preoperative therapy for pancreatic cancer",
abstract = "Purpose: Exercise concurrent with neoadjuvant chemotherapy and/or chemoradiation for pancreatic adenocarcinoma (PDAC) may mitigate the decline in function that may occur as a result of the disease or its treatment in the preoperative period. The primary objective of this single-arm prospective trial was to determine adherence to a home-based exercise program administered during preoperative therapy. Methods: Twenty patients from a quaternary cancer center with potentially resectable PDAC were enrolled. Patients were prescribed a minimum of 120 min of moderate-intensity exercise weekly: at least 60 min of aerobic exercise and 60 min of resistance exercise. Self-reported exercise was recorded in daily logs. Functional and survey measures were collected upon enrollment, following preoperative therapy, and 1 month after surgery. Results: Fifteen out of 20 patients participated in the program. They reported a mean (standard deviation (SD)) of 98.6 (69.8) min of aerobic exercise weekly and 57.4 (36.0) min of strengthening exercise weekly over a median of 17 weeks (range, 5–35 weeks) of preoperative therapy, for a mean (SD) of 156.0 (64.5) min of total exercise weekly. Eighty percent reported a mean of least 120 min of total exercise weekly during preoperative therapy. Patients with low baseline physical activity based on the International Physical Activity Questionnaire significantly increased their preoperative physical activity (p = .01). There were no adverse events associated with the exercise program. Conclusions: Patients with PDAC will participate in a home-based exercise program of aerobic and strengthening exercise and will increase physical activity, concurrent with preoperative chemotherapy and/or chemoradiation.",
keywords = "Cancer rehabilitation, Pancreatic cancer, Prehabilitation, Preoperative exercise",
author = "An Ngo-Huang and Parker, {Nathan H.} and Xuemei Wang and Petzel, {Maria Q.B.} and David Fogelman and Schadler, {Keri L.} and Eduardo Bruera and Fleming, {Jason B.} and Lee, {Jeffrey E.} and Katz, {Matthew H.G.}",
note = "Funding Information: PROMIS was funded with cooperative agreements from the National Institutes of Health Common Fund Initiative (U54AR057951, U01AR052177, U54AR057943, U54AR057926, U01AR057948, U01AR052170, U01AR057954, U01AR052171, U01AR052181, U01AR057956, U01AR052158, U01AR057929, U01AR057936, U01AR052155, U01AR057971, U01AR057940, U01AR057967, and U01AR052186). The contents of this article use data developed under PROMIS. These contents do not necessarily represent an endorsement by the US Federal Government or PROMIS. See www.nihpromis.org for additional information on the PROMIS initiative. Funding Information: This study used the Patient-Reported Outcomes, Survey, and Population Research Shared Resource, which is supported by a Cancer Center Support Grant (CA 016672, PI: R. DePinho, MD Anderson Cancer Center) from the National Cancer Institute, National Institutes of Health. We thank Karen Basen-Engquist, PhD, MPH of the Center for Energy Balance in Cancer Prevention and Survivorship, Duncan Family Institute for Cancer Prevention and Risk Assessment, MD Anderson Cancer Center, for her input on the research design. PROMIS was funded with cooperative agreements from the National Institutes of Health Common Fund Initiative (U54AR057951, U01AR052177, U54AR057943, U54AR057926, U01AR057948, U01AR052170, U01AR057954, U01AR052171, U01AR052181, U01AR057956, U01AR052158, U01AR057929, U01AR057936, U01AR052155, U01AR057971, U01AR057940, U01AR057967, and U01AR052186). The contents of this article use data developed under PROMIS. These contents do not necessarily represent an endorsement by the US Federal Government or PROMIS. See www.nihpromis.org for additional information on the PROMIS initiative. This study used the Patient-Reported Outcomes, Survey, and Population Research Shared Resource for exercise equipment, which is supported by a Cancer Center Support Grant (CA 016672, PI: R. DePinho, MD Anderson Cancer Center) from the National Cancer Institute, National Institutes of Health. The authors declare that they have no conflict of interest. Funding Information: Funding This study used the Patient-Reported Outcomes, Survey, and Population Research Shared Resource for exercise equipment, which is supported by a Cancer Center Support Grant (CA 016672, PI: R. DePinho, MD Anderson Cancer Center) from the National Cancer Institute, National Institutes of Health. Publisher Copyright: {\textcopyright} 2017, Springer-Verlag GmbH Germany.",
year = "2017",
month = dec,
day = "1",
doi = "10.1007/s00423-017-1599-0",
language = "English (US)",
volume = "402",
pages = "1175--1185",
journal = "Langenbeck's Archives of Surgery",
issn = "1435-2443",
publisher = "Springer Verlag",
number = "8",
}