TY - JOUR
T1 - Hormone exposure and its suppressive effect on risk of high-grade gliomas among patients with breast cancer
AU - Lopez-Garcia, Carlos A.
AU - Lopez-Rivera, Victor
AU - Dono, Antonio
AU - Salazar-Marioni, Sergio
AU - Novo, Jorge E.
AU - Sheth, Sunil A.
AU - Ballester, Leomar Y.
AU - Esquenazi, Yoshua
N1 - Funding Information:
Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number K08CA241651 (LYB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2021
PY - 2021/12
Y1 - 2021/12
N2 - Background: Prior reports demonstrate the expression of estrogen and progesterone receptors in high-grade gliomas (HGGs), but the relationship between hormone receptor-positive disease and risk of HHGs in patients with breast cancer (BC) remains uncharacterized. Methods: Using the SEER 18 registries (2000–2017), we examined the temporal trend of the incidence of HGGs and BC. The standardized incidence ratio was calculated to assess the risk of subsequent HGG in BC patients. Results: During the study period, the incidence of BC and HGGs remained comparable for men and women. Among 976,134 patients with BC, we found a decreased incidence of HGGs in females, but not in males. Female BC patients with hormone receptor-positive disease were at a lower risk of developing glioblastoma and anaplastic astrocytoma. Conclusion: Our study findings allude to the protective role of hormone exposure in the development of HGGs, which may lead to the development of therapies targeting hormonal pathways.
AB - Background: Prior reports demonstrate the expression of estrogen and progesterone receptors in high-grade gliomas (HGGs), but the relationship between hormone receptor-positive disease and risk of HHGs in patients with breast cancer (BC) remains uncharacterized. Methods: Using the SEER 18 registries (2000–2017), we examined the temporal trend of the incidence of HGGs and BC. The standardized incidence ratio was calculated to assess the risk of subsequent HGG in BC patients. Results: During the study period, the incidence of BC and HGGs remained comparable for men and women. Among 976,134 patients with BC, we found a decreased incidence of HGGs in females, but not in males. Female BC patients with hormone receptor-positive disease were at a lower risk of developing glioblastoma and anaplastic astrocytoma. Conclusion: Our study findings allude to the protective role of hormone exposure in the development of HGGs, which may lead to the development of therapies targeting hormonal pathways.
KW - Anaplastic astrocytoma
KW - Breast cancer
KW - Glioblastoma
KW - High-grade glioma
KW - Hormone exposure
KW - SEER
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U2 - 10.1016/j.jocn.2021.10.029
DO - 10.1016/j.jocn.2021.10.029
M3 - Article
C2 - 34863438
AN - SCOPUS:85118496159
SN - 0967-5868
VL - 94
SP - 200
EP - 203
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
ER -