Hormone Receptors in Breast Cancer and Response to Chemotherapy

Christian Sauter; M. Kaufmann; K. Klinga; B. Runnebaum; F. Kubli; Sewa S. Legha; George R. Blumenschien; Aman U. Buzdar; Gabriel N. Hortobagyi; Walter B. Panko; David T. Kiang; B. J. Kennedy; Daniel H. Frenning; Marc E. Lippman; Joseph C. Allegra

doi:10.1056/NEJM197905033001813

Hormone Receptors in Breast Cancer and Response to Chemotherapy

Christian Sauter, M. Kaufmann, K. Klinga, B. Runnebaum, F. Kubli, Sewa S. Legha, George R. Blumenschien, Aman U. Buzdar, Gabriel N. Hortobagyi, Walter B. Panko, David T. Kiang, B. J. Kennedy, Daniel H. Frenning, Marc E. Lippman, Joseph C. Allegra

Breast Medical Oncology

Research output: Contribution to journal › Letter › peer-review

11 Scopus citations

Abstract

To the Editor: The contradictory results presented by Lippman et al.¹ and Kiang et al.² on estrogen receptors and the treatment of breast cancer are not surprising. With the methods used by both groups, the quantity of receptors is expressed per amount of cytosol protein extracted. The number of tumor cells in each sample is, however, unknown. This number certainly varies a great deal; a given weight of medullary carcinoma, for example, may contain 100 times as many tumor cells as a scirrhous carcinoma. A real quantitative estrogen-receptor assay will only be possible and of value for routine clinical use.

Original language	English (US)
Pages (from-to)	1052-1054
Number of pages	3
Journal	New England Journal of Medicine
Volume	300
Issue number	18
DOIs	https://doi.org/10.1056/NEJM197905033001813
State	Published - May 3 1979

ASJC Scopus subject areas

General Medicine

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Sauter, C., Kaufmann, M., Klinga, K., Runnebaum, B., Kubli, F., Legha, S. S., Blumenschien, G. R., Buzdar, A. U., Hortobagyi, G. N., Panko, W. B., Kiang, D. T., Kennedy, B. J., Frenning, D. H., Lippman, M. E., & Allegra, J. C. (1979). Hormone Receptors in Breast Cancer and Response to Chemotherapy. New England Journal of Medicine, 300(18), 1052-1054. https://doi.org/10.1056/NEJM197905033001813

Sauter, C, Kaufmann, M, Klinga, K, Runnebaum, B, Kubli, F, Legha, SS, Blumenschien, GR, Buzdar, AU, Hortobagyi, GN, Panko, WB, Kiang, DT, Kennedy, BJ, Frenning, DH, Lippman, ME & Allegra, JC 1979, 'Hormone Receptors in Breast Cancer and Response to Chemotherapy', New England Journal of Medicine, vol. 300, no. 18, pp. 1052-1054. https://doi.org/10.1056/NEJM197905033001813

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title = "Hormone Receptors in Breast Cancer and Response to Chemotherapy",

abstract = "To the Editor: The contradictory results presented by Lippman et al.1 and Kiang et al.2 on estrogen receptors and the treatment of breast cancer are not surprising. With the methods used by both groups, the quantity of receptors is expressed per amount of cytosol protein extracted. The number of tumor cells in each sample is, however, unknown. This number certainly varies a great deal; a given weight of medullary carcinoma, for example, may contain 100 times as many tumor cells as a scirrhous carcinoma. A real quantitative estrogen-receptor assay will only be possible and of value for routine clinical use.",

author = "Christian Sauter and M. Kaufmann and K. Klinga and B. Runnebaum and F. Kubli and Legha, {Sewa S.} and Blumenschien, {George R.} and Buzdar, {Aman U.} and Hortobagyi, {Gabriel N.} and Panko, {Walter B.} and Kiang, {David T.} and Kennedy, {B. J.} and Frenning, {Daniel H.} and Lippman, {Marc E.} and Allegra, {Joseph C.}",

year = "1979",

month = may,

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doi = "10.1056/NEJM197905033001813",

language = "English (US)",

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T1 - Hormone Receptors in Breast Cancer and Response to Chemotherapy

AU - Sauter, Christian

AU - Kaufmann, M.

AU - Klinga, K.

AU - Runnebaum, B.

AU - Kubli, F.

AU - Legha, Sewa S.

AU - Blumenschien, George R.

AU - Buzdar, Aman U.

AU - Hortobagyi, Gabriel N.

AU - Panko, Walter B.

AU - Kiang, David T.

AU - Kennedy, B. J.

AU - Frenning, Daniel H.

AU - Lippman, Marc E.

AU - Allegra, Joseph C.

PY - 1979/5/3

Y1 - 1979/5/3

N2 - To the Editor: The contradictory results presented by Lippman et al.1 and Kiang et al.2 on estrogen receptors and the treatment of breast cancer are not surprising. With the methods used by both groups, the quantity of receptors is expressed per amount of cytosol protein extracted. The number of tumor cells in each sample is, however, unknown. This number certainly varies a great deal; a given weight of medullary carcinoma, for example, may contain 100 times as many tumor cells as a scirrhous carcinoma. A real quantitative estrogen-receptor assay will only be possible and of value for routine clinical use.

AB - To the Editor: The contradictory results presented by Lippman et al.1 and Kiang et al.2 on estrogen receptors and the treatment of breast cancer are not surprising. With the methods used by both groups, the quantity of receptors is expressed per amount of cytosol protein extracted. The number of tumor cells in each sample is, however, unknown. This number certainly varies a great deal; a given weight of medullary carcinoma, for example, may contain 100 times as many tumor cells as a scirrhous carcinoma. A real quantitative estrogen-receptor assay will only be possible and of value for routine clinical use.

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Hormone Receptors in Breast Cancer and Response to Chemotherapy

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