TY - CHAP
T1 - Hormones and Spermatogonial Development
AU - Meistrich, Marvin L.
AU - Shetty, Gunapala
AU - Bolden-Tiller, Olgau
AU - Porter, Karen L.
N1 - Publisher Copyright:
© 2005 Elsevier Inc. All rights reserved.
PY - 2005
Y1 - 2005
N2 - This chapter focuses on the effects of hormones on spermatogonial development. Two hormones, primarily T but also follicle-stimulating hormone (FSH), are required for the complete process of spermatogenesis in normal animals. Deprivation of T and FSH in rats and mice also reduces the numbers of spermatocytes and round spermatids to levels dependent on the residual concentrations of these hormones. The effects of T and FSH deprivation on spermatogonial numbers in rodents are moderate. In contrast, in adult primates (both human and monkey), the deprivation of these two hormones, especially FSH, primarily affects the conversion of type A pale to B spermatogonia, resulting in 90% reductions in B spermatogonial numbers, but there are only minor losses in the development of these B spermatogonia to spermatocytes and spermatids. The recovery of spermatogenesis in rats can be stimulated with hormone treatment given after irradiation, reversing the proliferation apoptosis (PAp) block to spermatogonial development. FSH can also inhibit spermatogonial differentiation in the models with a hormone dependent PAp block. © 2005
AB - This chapter focuses on the effects of hormones on spermatogonial development. Two hormones, primarily T but also follicle-stimulating hormone (FSH), are required for the complete process of spermatogenesis in normal animals. Deprivation of T and FSH in rats and mice also reduces the numbers of spermatocytes and round spermatids to levels dependent on the residual concentrations of these hormones. The effects of T and FSH deprivation on spermatogonial numbers in rodents are moderate. In contrast, in adult primates (both human and monkey), the deprivation of these two hormones, especially FSH, primarily affects the conversion of type A pale to B spermatogonia, resulting in 90% reductions in B spermatogonial numbers, but there are only minor losses in the development of these B spermatogonia to spermatocytes and spermatids. The recovery of spermatogenesis in rats can be stimulated with hormone treatment given after irradiation, reversing the proliferation apoptosis (PAp) block to spermatogonial development. FSH can also inhibit spermatogonial differentiation in the models with a hormone dependent PAp block. © 2005
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U2 - 10.1016/B978-012647751-1/50024-6
DO - 10.1016/B978-012647751-1/50024-6
M3 - Chapter
AN - SCOPUS:29344474805
SN - 9780126477511
SP - 437
EP - 448
BT - Sertoli Cell Biology
PB - Elsevier Inc.
ER -