TY - JOUR
T1 - How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
AU - López, Fernando
AU - Williams, Michelle D.
AU - Cardesa, Antonio
AU - Hunt, Jennifer L.
AU - Strojan, Primož
AU - Rinaldo, Alessandra
AU - Nixon, Iain J.
AU - Rodrigo, Juan P.
AU - Saba, Nabil F.
AU - Mendenhall, William M.
AU - Quer, Miquel
AU - Suárez, Carlos
AU - Ferlito, Alfio
N1 - Publisher Copyright:
© 2017, Springer-Verlag Berlin Heidelberg.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Although the majority of laryngeal malignancies are the conventional squamous cell carcinomas (SCC), a wide variety of malignant epithelial tumors can affect the larynx. Current treatment guidelines are designed to guide clinicians in management of conventional laryngeal SCC. Less is known about the biological behavior and responsiveness to therapy and overall outcomes of other malignant epithelial lesions. Because a spectrum of disease biology is represented by these rare phenotypes, an understanding of the basic biology can help direct management to optimize clinical outcome in this group of patients. This review provides a critical analysis of literature relating to the diagnosis, management, and outcome of patients with non-conventional squamous malignant epithelial neoplasms of the larynx. Particular attention is paid to features which are at variance with the conventional SCC and how these impact on management of these rare tumors.
AB - Although the majority of laryngeal malignancies are the conventional squamous cell carcinomas (SCC), a wide variety of malignant epithelial tumors can affect the larynx. Current treatment guidelines are designed to guide clinicians in management of conventional laryngeal SCC. Less is known about the biological behavior and responsiveness to therapy and overall outcomes of other malignant epithelial lesions. Because a spectrum of disease biology is represented by these rare phenotypes, an understanding of the basic biology can help direct management to optimize clinical outcome in this group of patients. This review provides a critical analysis of literature relating to the diagnosis, management, and outcome of patients with non-conventional squamous malignant epithelial neoplasms of the larynx. Particular attention is paid to features which are at variance with the conventional SCC and how these impact on management of these rare tumors.
KW - Acantholytic squamous cell carcinoma
KW - Adenosquamous carcinoma larynx
KW - Basaloid squamous cell carcinoma
KW - Histology
KW - Laryngeal cancer
KW - Lymphoepithelial carcinoma
KW - Non-keratinizing HPV-positive squamous cell carcinoma
KW - Papillary squamous cell carcinoma
KW - Spindle cell carcinoma
KW - Verrucous squamous cell carcinoma
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U2 - 10.1007/s00405-017-4533-8
DO - 10.1007/s00405-017-4533-8
M3 - Review article
C2 - 28364287
AN - SCOPUS:85016477005
SN - 0937-4477
VL - 274
SP - 2709
EP - 2726
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
IS - 7
ER -