Abstract
Objective This review aimed to critically analyse data pertaining to the clinical presentation and treatment of neuroendocrine carcinomas of the larynx.Method A PubMed search was performed using the term 'neuroendocrine carcinoma'. English-language articles on neuroendocrine carcinoma of the larynx were reviewed in detail.Results and conclusion While many historical classifications have been proposed, in contemporary practice these tumours are sub-classified into four subtypes: carcinoid, atypical carcinoid, small cell neuroendocrine carcinoma and large cell neuroendocrine carcinoma. These tumours exhibit a wide range of biological behaviour, ranging from the extremely aggressive nature of small and large cell neuroendocrine carcinomas, which usually have a fatal prognosis, to the less aggressive course of carcinoid tumours. In small and large cell neuroendocrine carcinomas, a combination of irradiation and chemotherapy is indicated, while carcinoid and atypical carcinoid tumour management entails conservation surgery.
Original language | English (US) |
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Pages (from-to) | 568-574 |
Number of pages | 7 |
Journal | Journal of Laryngology and Otology |
Volume | 132 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2018 |
Keywords
- Carcinoid Tumors
- Laryngeal Cancer
- Larynx
- Neuroendocrine Carcinoma
- Neuroendocrine Tumors
ASJC Scopus subject areas
- Otorhinolaryngology