TY - JOUR
T1 - How the microenvironment shapes chronic lymphocytic leukemia
T2 - The cytoskeleton connection
AU - Scielzo, Cristina
AU - Ten Hacken, Elisa
AU - Bertilaccio, Maria T.S.
AU - Muzio, Marta
AU - Calissano, Carlo
AU - Ghia, Paolo
AU - Caligaris-Cappio, Federico
N1 - Funding Information:
by the Associazione Italiana per la Ricerca sul Cancro – AIRC, Fondazione Italiana per la Ricerca sul Cancro – FIRC, ‘Fondazione Piera, Pietro e Giovanni Ferrero,’ EHA Fellowship Program, ‘CLLGRF – US/European Alliance for the Therapy of CLL,’ and Progetti Integrati Oncologia (PIO) – Ministero della Salute.
PY - 2010/8
Y1 - 2010/8
N2 - Chronic lymphocytic leukemia (CLL) is characterized by the accumulation in primary and secondary lymphoid tissues of CD5B cells that have the same B cell receptor (BCR) rearrangement. Genetic alterations and different stimuli originating from the microenvironment cooperate in the selection and expansion of the malignant clone. Molecular and functional analyses suggest that stimulation through the BCR affects the destiny of leukemic cells in terms of life or death. Microenvironmental signals are crucial for this process, inducing proliferation and leading to the survival and accumulation of leukemic cells within lymphoid organs. Nevertheless, a number of major biological issues still remain to be solved, including the relationships between cell proliferation and cell accumulation within lymphoid organs as well as the mechanisms that regulate CLL cell migration and recirculation between peripheral blood and lymphoid tissues. We focused on the role played by the cytoskeleton, given its relevance in controlling cellular shape, mobility, and homing. We hypothesize that hematopoietic cell-specific Lyn substrate 1 (HS1), a putative prognostic marker in CLL that interacts with distinct cytoskeleton adapters in leukemic B-lymphocytes, could regulate the CLL cell cytoskeleton.
AB - Chronic lymphocytic leukemia (CLL) is characterized by the accumulation in primary and secondary lymphoid tissues of CD5B cells that have the same B cell receptor (BCR) rearrangement. Genetic alterations and different stimuli originating from the microenvironment cooperate in the selection and expansion of the malignant clone. Molecular and functional analyses suggest that stimulation through the BCR affects the destiny of leukemic cells in terms of life or death. Microenvironmental signals are crucial for this process, inducing proliferation and leading to the survival and accumulation of leukemic cells within lymphoid organs. Nevertheless, a number of major biological issues still remain to be solved, including the relationships between cell proliferation and cell accumulation within lymphoid organs as well as the mechanisms that regulate CLL cell migration and recirculation between peripheral blood and lymphoid tissues. We focused on the role played by the cytoskeleton, given its relevance in controlling cellular shape, mobility, and homing. We hypothesize that hematopoietic cell-specific Lyn substrate 1 (HS1), a putative prognostic marker in CLL that interacts with distinct cytoskeleton adapters in leukemic B-lymphocytes, could regulate the CLL cell cytoskeleton.
KW - CLL
KW - Cytoskeleton
KW - Microenviroment
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U2 - 10.3109/10428194.2010.505061
DO - 10.3109/10428194.2010.505061
M3 - Article
C2 - 20687794
AN - SCOPUS:77955444557
SN - 1042-8194
VL - 51
SP - 1371
EP - 1374
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 8
ER -