TY - JOUR
T1 - How to Define and Manage Borderline Resectable Pancreatic Cancer
AU - Papavasiliou, Pavlos
AU - Chun, Yun Shin
AU - Hoffman, John P.
PY - 2013/6
Y1 - 2013/6
N2 - Historically, borderline resectable (BLR) pancreatic cancer has had many definitions, which has made interpretation of treatment data and outcomes difficult. Advances in imaging, surgical technique, and the potential benefit of neoadjuvant therapy have emphasized the need for uniform classification. Despite recent efforts to provide a clearer definition, prospective randomized trials are lacking in the literature. This article reviews current definitions, treatment sequences, outcomes, and prognostic factors associated with BLR pancreatic cancer. Further clarification and consensus on the definition of BLR pancreatic cancer will allow for further data collection and cooperation in future efforts to make progress and standardize treatment.
AB - Historically, borderline resectable (BLR) pancreatic cancer has had many definitions, which has made interpretation of treatment data and outcomes difficult. Advances in imaging, surgical technique, and the potential benefit of neoadjuvant therapy have emphasized the need for uniform classification. Despite recent efforts to provide a clearer definition, prospective randomized trials are lacking in the literature. This article reviews current definitions, treatment sequences, outcomes, and prognostic factors associated with BLR pancreatic cancer. Further clarification and consensus on the definition of BLR pancreatic cancer will allow for further data collection and cooperation in future efforts to make progress and standardize treatment.
KW - Borderline resectable pancreatic cancer
KW - Neoadjuvant therapy
KW - Surgical techniques
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U2 - 10.1016/j.suc.2013.02.005
DO - 10.1016/j.suc.2013.02.005
M3 - Review article
C2 - 23632151
AN - SCOPUS:84876958436
SN - 0039-6109
VL - 93
SP - 663
EP - 674
JO - Surgical Clinics of North America
JF - Surgical Clinics of North America
IS - 3
ER -