HPV-induced oropharyngeal cancer, immune response and response to therapy

Ha Linh Vu; Andrew G. Sikora; Shibo Fu; Johnny Kao

doi:10.1016/j.canlet.2009.06.026

HPV-induced oropharyngeal cancer, immune response and response to therapy

Ha Linh Vu, Andrew G. Sikora, Shibo Fu, Johnny Kao

Research output: Contribution to journal › Review article › peer-review

64 Scopus citations

Abstract

Approximately 25% of head and neck squamous cell carcinoma (HNSCC) worldwide are associated with high-risk human papillomaviruses (HPV). HPV-positive HNSCCs have a more favorable outcome and greater response to therapy. While chronic HPV infection allows for the evolution of immune evasion mechanisms, viral antigens can still elicit an immune response. Moreover, a robust lymphocytic response is associated with better prognosis in a variety of tumor types including head and neck cancer. This article outlines several mechanisms whereby the observed improved response of HPV-positive tumors to radiotherapy may be related to enhancement of the immune response following radiotherapy.

Original language	English (US)
Pages (from-to)	149-155
Number of pages	7
Journal	Cancer Letters
Volume	288
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2009.06.026
State	Published - Feb 28 2010
Externally published	Yes

Keywords

HPV
Head and neck squamous cell carcinoma
Immune surveillance
Radiation

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2009.06.026

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title = "HPV-induced oropharyngeal cancer, immune response and response to therapy",

abstract = "Approximately 25% of head and neck squamous cell carcinoma (HNSCC) worldwide are associated with high-risk human papillomaviruses (HPV). HPV-positive HNSCCs have a more favorable outcome and greater response to therapy. While chronic HPV infection allows for the evolution of immune evasion mechanisms, viral antigens can still elicit an immune response. Moreover, a robust lymphocytic response is associated with better prognosis in a variety of tumor types including head and neck cancer. This article outlines several mechanisms whereby the observed improved response of HPV-positive tumors to radiotherapy may be related to enhancement of the immune response following radiotherapy.",

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AU - Vu, Ha Linh

AU - Sikora, Andrew G.

AU - Fu, Shibo

AU - Kao, Johnny

PY - 2010/2/28

Y1 - 2010/2/28

N2 - Approximately 25% of head and neck squamous cell carcinoma (HNSCC) worldwide are associated with high-risk human papillomaviruses (HPV). HPV-positive HNSCCs have a more favorable outcome and greater response to therapy. While chronic HPV infection allows for the evolution of immune evasion mechanisms, viral antigens can still elicit an immune response. Moreover, a robust lymphocytic response is associated with better prognosis in a variety of tumor types including head and neck cancer. This article outlines several mechanisms whereby the observed improved response of HPV-positive tumors to radiotherapy may be related to enhancement of the immune response following radiotherapy.

AB - Approximately 25% of head and neck squamous cell carcinoma (HNSCC) worldwide are associated with high-risk human papillomaviruses (HPV). HPV-positive HNSCCs have a more favorable outcome and greater response to therapy. While chronic HPV infection allows for the evolution of immune evasion mechanisms, viral antigens can still elicit an immune response. Moreover, a robust lymphocytic response is associated with better prognosis in a variety of tumor types including head and neck cancer. This article outlines several mechanisms whereby the observed improved response of HPV-positive tumors to radiotherapy may be related to enhancement of the immune response following radiotherapy.

KW - HPV

KW - Head and neck squamous cell carcinoma

KW - Immune surveillance

KW - Radiation

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DO - 10.1016/j.canlet.2009.06.026

M3 - Review article

C2 - 19628331

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SN - 0304-3835

VL - 288

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JO - Cancer Letters

JF - Cancer Letters

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ER -

HPV-induced oropharyngeal cancer, immune response and response to therapy

Abstract

Keywords

ASJC Scopus subject areas

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