HSP90, a chaperone that can make you SYK

Elisa Ten Hacken; Jan A. Burger

doi:10.1182/blood-2016-12-753152

HSP90, a chaperone that can make you SYK

Elisa Ten Hacken, Jan A. Burger

Leukemia

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

In this issue of Blood, Walter et al demonstrate an association between heat shock protein 90 (HSP90) and spleen tyrosine kinase (SYK) as a critical upstream component in tonic BCR signaling of Burkitt lymphoma (BL). Integrity of this HSP90-SYK complex appears to be critical for maintenance of tonic BCR signaling, which keeps BL cells alive. Consequently, the authors propose HSP90 as a novel therapeutic target in BL.¹.

Original language	English (US)
Pages (from-to)	542-544
Number of pages	3
Journal	Blood
Volume	129
Issue number	5
DOIs	https://doi.org/10.1182/blood-2016-12-753152
State	Published - Feb 2 2017

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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abstract = "In this issue of Blood, Walter et al demonstrate an association between heat shock protein 90 (HSP90) and spleen tyrosine kinase (SYK) as a critical upstream component in tonic BCR signaling of Burkitt lymphoma (BL). Integrity of this HSP90-SYK complex appears to be critical for maintenance of tonic BCR signaling, which keeps BL cells alive. Consequently, the authors propose HSP90 as a novel therapeutic target in BL.1.",

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AU - Burger, Jan A.

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AB - In this issue of Blood, Walter et al demonstrate an association between heat shock protein 90 (HSP90) and spleen tyrosine kinase (SYK) as a critical upstream component in tonic BCR signaling of Burkitt lymphoma (BL). Integrity of this HSP90-SYK complex appears to be critical for maintenance of tonic BCR signaling, which keeps BL cells alive. Consequently, the authors propose HSP90 as a novel therapeutic target in BL.1.

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HSP90, a chaperone that can make you SYK

Abstract

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