H₂O₂ induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism

Medicine & Life Sciences

• Cell Nucleus Active Transport 100%
• Cytoplasmic and Nuclear Receptors 87%
• Protein-Tyrosine Kinases 77%
• Reactive Oxygen Species 68%
• Breast Neoplasms 54%
• Membranes 50%
• SEC Translocation Channels 29%
• Coatomer Protein 28%
• Cell Membrane 24%
• Proto-Oncogene Proteins c-met 23%
• Poly(ADP-ribose) Polymerase Inhibitors 22%
• Transport Vesicles 22%
• Protein Subunits 19%
• Proteins 18%
• Receptor Protein-Tyrosine Kinases 18%
• Neoplasms 16%
• Antineoplastic Agents 16%
• Cell Movement 13%
• Signal Transduction 13%
• Phosphotransferases 13%
• Cell Survival 12%
• Oxidative Stress 12%
• Up-Regulation 12%
• Cell Proliferation 11%
• Lipids 11%
• Drug Therapy 9%
• DNA 9%
• Pharmaceutical Preparations 7%

Chemistry

• Tyrosine 77%
• Reactive Oxygen Metabolite 59%
• Poly(ADPribose) 58%
• Protein 35%
• Oxidative Stress 21%
• Cell Viability 21%
• Dioxygen 20%
• Antineoplastic Agent 18%
• Pharmacological Metabolism 16%
• Lipid 14%
• Resistance 13%
• Plasma 13%
• Drug 11%