Human CD38: A (r)evolutionary story of enzymes and receptors

Silvia Deaglio; Kapil Mehta; Fabio Malavasi

doi:10.1016/S0145-2126(00)00093-X

Human CD38: A (r)evolutionary story of enzymes and receptors

Silvia Deaglio, Kapil Mehta, Fabio Malavasi

Experimental Therapeutics

Research output: Contribution to journal › Short survey › peer-review

246 Scopus citations

Abstract

Human CD38 is the mammalian prototype of a family of proteins which share structural similarities and an ectoenzymatic activity involved in the production of calcium mobilizing compounds. Besides the enzymatic activity, the molecule performs as a receptor, ruling adhesion and signaling in leukocytes. These functions are exerted through the interaction with surface ligands, one of which was identified as CD31. Recently, CD38 has gained attention as a prognostic marker and a pathogenetic agent in leukemias and in other diseases. Together these insights have produced a model of an as yet unique family of molecules, which act independently as receptors and enzymes.

Original language	English (US)
Pages (from-to)	1-12
Number of pages	12
Journal	Leukemia Research
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/S0145-2126(00)00093-X
State	Published - 2001

Keywords

AML
APL
B-CLL
CD157
CD38
Ectoenzymes
Receptors
Signaling pathway

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/S0145-2126(00)00093-X

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title = "Human CD38: A (r)evolutionary story of enzymes and receptors",

abstract = "Human CD38 is the mammalian prototype of a family of proteins which share structural similarities and an ectoenzymatic activity involved in the production of calcium mobilizing compounds. Besides the enzymatic activity, the molecule performs as a receptor, ruling adhesion and signaling in leukocytes. These functions are exerted through the interaction with surface ligands, one of which was identified as CD31. Recently, CD38 has gained attention as a prognostic marker and a pathogenetic agent in leukemias and in other diseases. Together these insights have produced a model of an as yet unique family of molecules, which act independently as receptors and enzymes.",

keywords = "AML, APL, B-CLL, CD157, CD38, Ectoenzymes, Receptors, Signaling pathway",

author = "Silvia Deaglio and Kapil Mehta and Fabio Malavasi",

note = "Funding Information: This work was supported by grants from AIRC, Telethon, Special Projects {\textquoteleft}AIDS{\textquoteright} (Istituto Superiore di Sanit{\`a}, Roma, Italy) and {\textquoteleft}Biotechnology{\textquoteright} (CNR/MURST, Roma, Italy) and MURST (Cofinanziamento). The Compagnia di Sanpaolo, Cariverona and Ghirotti Foundations and Regione Piemonte provided valuable financial contributions. Silvia Deaglio is a student of the Postgraduate School of Medical Oncology, University of Torino Medical School, Torino, Italy. All authors contributed equally to this work. All co-authors contributed equally to this effort.",

year = "2001",

doi = "10.1016/S0145-2126(00)00093-X",

language = "English (US)",

volume = "25",

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T1 - Human CD38

T2 - A (r)evolutionary story of enzymes and receptors

AU - Deaglio, Silvia

AU - Mehta, Kapil

AU - Malavasi, Fabio

N1 - Funding Information: This work was supported by grants from AIRC, Telethon, Special Projects ‘AIDS’ (Istituto Superiore di Sanità, Roma, Italy) and ‘Biotechnology’ (CNR/MURST, Roma, Italy) and MURST (Cofinanziamento). The Compagnia di Sanpaolo, Cariverona and Ghirotti Foundations and Regione Piemonte provided valuable financial contributions. Silvia Deaglio is a student of the Postgraduate School of Medical Oncology, University of Torino Medical School, Torino, Italy. All authors contributed equally to this work. All co-authors contributed equally to this effort.

PY - 2001

Y1 - 2001

N2 - Human CD38 is the mammalian prototype of a family of proteins which share structural similarities and an ectoenzymatic activity involved in the production of calcium mobilizing compounds. Besides the enzymatic activity, the molecule performs as a receptor, ruling adhesion and signaling in leukocytes. These functions are exerted through the interaction with surface ligands, one of which was identified as CD31. Recently, CD38 has gained attention as a prognostic marker and a pathogenetic agent in leukemias and in other diseases. Together these insights have produced a model of an as yet unique family of molecules, which act independently as receptors and enzymes.

AB - Human CD38 is the mammalian prototype of a family of proteins which share structural similarities and an ectoenzymatic activity involved in the production of calcium mobilizing compounds. Besides the enzymatic activity, the molecule performs as a receptor, ruling adhesion and signaling in leukocytes. These functions are exerted through the interaction with surface ligands, one of which was identified as CD31. Recently, CD38 has gained attention as a prognostic marker and a pathogenetic agent in leukemias and in other diseases. Together these insights have produced a model of an as yet unique family of molecules, which act independently as receptors and enzymes.

KW - AML

KW - APL

KW - B-CLL

KW - CD157

KW - CD38

KW - Ectoenzymes

KW - Receptors

KW - Signaling pathway

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DO - 10.1016/S0145-2126(00)00093-X

M3 - Short survey

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AN - SCOPUS:0035177850

SN - 0145-2126

VL - 25

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JO - Leukemia Research

JF - Leukemia Research

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ER -

Human CD38: A (r)evolutionary story of enzymes and receptors

Abstract

Keywords

ASJC Scopus subject areas

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