Human globin locus activation region (LAR): role in temporal control

Tim M. Townes; Richard R. Behringer

doi:10.1016/0168-9525(90)90182-6

Human globin locus activation region (LAR): role in temporal control

Tim M. Townes, Richard R. Behringer

Research output: Contribution to journal › Article › peer-review

169 Scopus citations

Abstract

A region of DNA located for upstream of the human β-globin locus is critically involved in the regulation of the β-globin gene family. Recent experiments in transgenic mice suggest that switching from fetal to adult globin gene expression during human development results from competition among individual globin gene family members for interaction with sequences in this region. The phenotypes of patients with defined hemoglobinopathies support this hypothesis.

Original language	English (US)
Pages (from-to)	219-222
Number of pages	4
Journal	Trends in Genetics
Volume	6
Issue number	C
DOIs	https://doi.org/10.1016/0168-9525(90)90182-6
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1016/0168-9525(90)90182-6

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title = "Human globin locus activation region (LAR): role in temporal control",

abstract = "A region of DNA located for upstream of the human β-globin locus is critically involved in the regulation of the β-globin gene family. Recent experiments in transgenic mice suggest that switching from fetal to adult globin gene expression during human development results from competition among individual globin gene family members for interaction with sequences in this region. The phenotypes of patients with defined hemoglobinopathies support this hypothesis.",

author = "Townes, {Tim M.} and Behringer, {Richard R.}",

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AU - Behringer, Richard R.

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N2 - A region of DNA located for upstream of the human β-globin locus is critically involved in the regulation of the β-globin gene family. Recent experiments in transgenic mice suggest that switching from fetal to adult globin gene expression during human development results from competition among individual globin gene family members for interaction with sequences in this region. The phenotypes of patients with defined hemoglobinopathies support this hypothesis.

AB - A region of DNA located for upstream of the human β-globin locus is critically involved in the regulation of the β-globin gene family. Recent experiments in transgenic mice suggest that switching from fetal to adult globin gene expression during human development results from competition among individual globin gene family members for interaction with sequences in this region. The phenotypes of patients with defined hemoglobinopathies support this hypothesis.

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U2 - 10.1016/0168-9525(90)90182-6

DO - 10.1016/0168-9525(90)90182-6

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JO - Trends in Genetics

JF - Trends in Genetics

IS - C

ER -

Human globin locus activation region (LAR): role in temporal control

Abstract

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