Abstract
Our current understanding of Kaposi's sarcoma (KS) has evolved from initial descriptions of this 'idiopathic sarcoma' to a progressively detailed characterization of its probable infectious origin. This article traces the explosive discovery of human herpesvirus-8 (HHV-8) and its etiologic associations with KS, Castleman's disease, and primary effusion lymphomas. A framework for understanding how viral infection leads to development of these unusual diseases is presented. The possible role of HHV-8 in tumorigenesis, through viral manipulation of signal transduction pathways and cell cycle control, is discussed.
Original language | English (US) |
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Pages (from-to) | 440-449 |
Number of pages | 10 |
Journal | Current opinion in oncology |
Volume | 9 |
Issue number | 5 |
DOIs | |
State | Published - 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research