TY - JOUR
T1 - Human monocytes activated by immunomodulators in liposomes lyse herpesvirus-infected but not normal cells
AU - Koff, Wayne C.
AU - Fidler, Isaiah J
AU - Showalter, Stephen D.
AU - Chakrabarty, Mrinal K.
AU - Hampar, Berge
AU - Ceccorulli, Lisa M.
AU - Kleinerman, Eugenie S.
PY - 1984
Y1 - 1984
N2 - Highly purified peripheral blood monocytes from normal human donors were activated in vitro by incubation with liposomes containing immunomodulators such as recombinant human gamma interferon, human lymphokines, or muramyl dipeptide. The ability of liposomes containing immunomodulators to activate monocytes to a cytotoxic state capable of discriminating between virus-infected and uninfected cells was shown by activated monocytes recognizing and destroying herpes simplex virus type 2-infected cells while leaving uninfected cells unharmed.
AB - Highly purified peripheral blood monocytes from normal human donors were activated in vitro by incubation with liposomes containing immunomodulators such as recombinant human gamma interferon, human lymphokines, or muramyl dipeptide. The ability of liposomes containing immunomodulators to activate monocytes to a cytotoxic state capable of discriminating between virus-infected and uninfected cells was shown by activated monocytes recognizing and destroying herpes simplex virus type 2-infected cells while leaving uninfected cells unharmed.
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U2 - 10.1126/science.6426057
DO - 10.1126/science.6426057
M3 - Article
C2 - 6426057
AN - SCOPUS:0021248897
SN - 0036-8075
VL - 224
SP - 1007
EP - 1009
JO - Science
JF - Science
IS - 4652
ER -