Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer

Yukiko Yasuda; Akiko Sakai; Sachio Ito; Kaori Sasai; Akisada Ishizaki; Yoshiya Okano; Seito Kawahara; Yoshimi Jitsumori; Hiromasa Yamamoto; Nagahide Matsubara; Kenji Shimizu; Hiroshi Katayama

doi:10.3892/br.2020.1352

Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer

Yukiko Yasuda, Akiko Sakai, Sachio Ito, Kaori Sasai, Akisada Ishizaki, Yoshiya Okano, Seito Kawahara, Yoshimi Jitsumori, Hiromasa Yamamoto, Nagahide Matsubara, Kenji Shimizu, Hiroshi Katayama

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

NINEIN serves an essential role in centrosome function as a microtubule organizing center, and in the refor-mation of the interphase centrosome architecture following mitosis. In the present study, the association between NINEIN Pro1111Ala (rs2236316), a missense single nucleotide poly-morphism, and the risk of colorectal cancer (CRC), related to smoking and alcohol consumption habits in 200 patients with CRC and 1,141 cancer-free control participants were assessed in a case-control study performed in Japan. The results showed that the NINEIN Ala/Ala genotype compared with the Pro/Pro genotype was significantly more associated with an increased risk of CRC, and the males with the Ala/Ala genotype exhib-ited a significantly increased risk of CRC compared with those with Pro/Pro and Pro/Ala genotypes. Stratified analyses of the Ala/Ala genotype with CRC risk further showed an increased association in never/light drinkers (<23 g of ethanol/day), in male never/light drinkers and in male patients with rectal cancer. These findings suggest that the genetic variant of the NINEIN Pro1111Ala polymorphism has a significant effect on CRC susceptibility in the Japanese population.

Original language	English (US)
Article number	45
Pages (from-to)	1-11
Number of pages	11
Journal	Biomedical Reports
Volume	13
Issue number	5
DOIs	https://doi.org/10.3892/br.2020.1352
State	Published - 2020
Externally published	Yes

Keywords

Centrosome
Colon cancer
NINEIN
Single nucleotide polymorphism
Tumor susceptibility

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.3892/br.2020.1352

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@article{c996aa56c54b420191c7338602033429,

title = "Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer",

abstract = "NINEIN serves an essential role in centrosome function as a microtubule organizing center, and in the refor-mation of the interphase centrosome architecture following mitosis. In the present study, the association between NINEIN Pro1111Ala (rs2236316), a missense single nucleotide poly-morphism, and the risk of colorectal cancer (CRC), related to smoking and alcohol consumption habits in 200 patients with CRC and 1,141 cancer-free control participants were assessed in a case-control study performed in Japan. The results showed that the NINEIN Ala/Ala genotype compared with the Pro/Pro genotype was significantly more associated with an increased risk of CRC, and the males with the Ala/Ala genotype exhib-ited a significantly increased risk of CRC compared with those with Pro/Pro and Pro/Ala genotypes. Stratified analyses of the Ala/Ala genotype with CRC risk further showed an increased association in never/light drinkers (<23 g of ethanol/day), in male never/light drinkers and in male patients with rectal cancer. These findings suggest that the genetic variant of the NINEIN Pro1111Ala polymorphism has a significant effect on CRC susceptibility in the Japanese population.",

keywords = "Centrosome, Colon cancer, NINEIN, Single nucleotide polymorphism, Tumor susceptibility",

author = "Yukiko Yasuda and Akiko Sakai and Sachio Ito and Kaori Sasai and Akisada Ishizaki and Yoshiya Okano and Seito Kawahara and Yoshimi Jitsumori and Hiromasa Yamamoto and Nagahide Matsubara and Kenji Shimizu and Hiroshi Katayama",

note = "Funding Information: The authors would like to thank Mrs Hiroko Hanafusa and Dr Norio Koide (Okayama University School of Medicine), Dr Yoshiro Kusaka (Kusaka Hospital), Dr Seiji Hamanishi and Dr Etsuo Senoh (Junpukai Health Maintenance Center) for their generous help in this study. Funding This work was supported by a Research start-up grant from Okayama University Graduate School of Medicine, Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology (grant no. 12213084 and JP18K15752) and the Smoking Research Foundation. Funding Information: This work was supported by a Research start‑up grant from Okayama University Graduate School of Medicine, Grant‑in‑Aid from the Ministry of Education, Culture, Sports, Science and Technology (grant no. 12213084 and JP18K15752) and the Smoking Research Foundation. Publisher Copyright: {\textcopyright} 2020, Spandidos Publications. All rights reserved.",

year = "2020",

doi = "10.3892/br.2020.1352",

language = "English (US)",

volume = "13",

pages = "1--11",

journal = "Biomedical Reports",

issn = "2049-9434",

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T1 - Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer

AU - Yasuda, Yukiko

AU - Sakai, Akiko

AU - Ito, Sachio

AU - Sasai, Kaori

AU - Ishizaki, Akisada

AU - Okano, Yoshiya

AU - Kawahara, Seito

AU - Jitsumori, Yoshimi

AU - Yamamoto, Hiromasa

AU - Matsubara, Nagahide

AU - Shimizu, Kenji

AU - Katayama, Hiroshi

N1 - Funding Information: The authors would like to thank Mrs Hiroko Hanafusa and Dr Norio Koide (Okayama University School of Medicine), Dr Yoshiro Kusaka (Kusaka Hospital), Dr Seiji Hamanishi and Dr Etsuo Senoh (Junpukai Health Maintenance Center) for their generous help in this study. Funding This work was supported by a Research start-up grant from Okayama University Graduate School of Medicine, Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology (grant no. 12213084 and JP18K15752) and the Smoking Research Foundation. Funding Information: This work was supported by a Research start‑up grant from Okayama University Graduate School of Medicine, Grant‑in‑Aid from the Ministry of Education, Culture, Sports, Science and Technology (grant no. 12213084 and JP18K15752) and the Smoking Research Foundation. Publisher Copyright: © 2020, Spandidos Publications. All rights reserved.

PY - 2020

Y1 - 2020

N2 - NINEIN serves an essential role in centrosome function as a microtubule organizing center, and in the refor-mation of the interphase centrosome architecture following mitosis. In the present study, the association between NINEIN Pro1111Ala (rs2236316), a missense single nucleotide poly-morphism, and the risk of colorectal cancer (CRC), related to smoking and alcohol consumption habits in 200 patients with CRC and 1,141 cancer-free control participants were assessed in a case-control study performed in Japan. The results showed that the NINEIN Ala/Ala genotype compared with the Pro/Pro genotype was significantly more associated with an increased risk of CRC, and the males with the Ala/Ala genotype exhib-ited a significantly increased risk of CRC compared with those with Pro/Pro and Pro/Ala genotypes. Stratified analyses of the Ala/Ala genotype with CRC risk further showed an increased association in never/light drinkers (<23 g of ethanol/day), in male never/light drinkers and in male patients with rectal cancer. These findings suggest that the genetic variant of the NINEIN Pro1111Ala polymorphism has a significant effect on CRC susceptibility in the Japanese population.

AB - NINEIN serves an essential role in centrosome function as a microtubule organizing center, and in the refor-mation of the interphase centrosome architecture following mitosis. In the present study, the association between NINEIN Pro1111Ala (rs2236316), a missense single nucleotide poly-morphism, and the risk of colorectal cancer (CRC), related to smoking and alcohol consumption habits in 200 patients with CRC and 1,141 cancer-free control participants were assessed in a case-control study performed in Japan. The results showed that the NINEIN Ala/Ala genotype compared with the Pro/Pro genotype was significantly more associated with an increased risk of CRC, and the males with the Ala/Ala genotype exhib-ited a significantly increased risk of CRC compared with those with Pro/Pro and Pro/Ala genotypes. Stratified analyses of the Ala/Ala genotype with CRC risk further showed an increased association in never/light drinkers (<23 g of ethanol/day), in male never/light drinkers and in male patients with rectal cancer. These findings suggest that the genetic variant of the NINEIN Pro1111Ala polymorphism has a significant effect on CRC susceptibility in the Japanese population.

KW - Centrosome

KW - Colon cancer

KW - NINEIN

KW - Single nucleotide polymorphism

KW - Tumor susceptibility

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DO - 10.3892/br.2020.1352

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AN - SCOPUS:85091095561

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JF - Biomedical Reports

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ER -

Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer

Abstract

Keywords

ASJC Scopus subject areas

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