Human Papillomavirus in Laryngeal and Hypopharyngeal Carcinomas: Relationship to Survival

Gary L Clayman; Michael G. Stewart; Randal S. Weber; Adel K. El-Naggar; Elizabeth A Grimm

doi:10.1001/archotol.1994.01880310047009

Human Papillomavirus in Laryngeal and Hypopharyngeal Carcinomas: Relationship to Survival

Gary L Clayman, Michael G. Stewart, Randal S. Weber, Adel K. El-Naggar, Elizabeth A Grimm

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Objective: To determine the relationship between human papillomavirus (HPV) DNA detection in upper aerodigestive tract malignancies and patient outcome. Design: Archival paraffin-embedded specimens from 78 previously untreated patients with squamous carcinomas of the larynx and hypopharynx were pathologically verified and analyzed by polymerase chain reaction for detection of HPV DNA. Charts were independently reviewed and coded until final analysis. Setting: The University of Texas M. D. Anderson Cancer Center, Houston, a tertiary cancer referral center. Results: DNA was successfully extracted from 65 archival patient samples (83%). The mean (±SEM) duration of follow-up for these patients was 42±21 months. Thirty specimens (46%) exhibited detectable HPV DNA. Detection of HPV was significantly related to decreased survival, independent of disease stage. Log rank testing revealed that HPV detection, pathologic vascular invasion, and nodal status were the most significant predictors of death of disease. Conclusions: Laryngeal and hypopharyngeal carcinomas with detectable HPV may represent a biologically distinct subset of tumors that carry a poorer prognosis than do cancers with no detectable HPV.

Original language	English (US)
Pages (from-to)	743-748
Number of pages	6
Journal	Archives of Otolaryngology--Head and Neck Surgery
Volume	120
Issue number	7
DOIs	https://doi.org/10.1001/archotol.1994.01880310047009
State	Published - Jul 1994

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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title = "Human Papillomavirus in Laryngeal and Hypopharyngeal Carcinomas: Relationship to Survival",

abstract = "Objective: To determine the relationship between human papillomavirus (HPV) DNA detection in upper aerodigestive tract malignancies and patient outcome. Design: Archival paraffin-embedded specimens from 78 previously untreated patients with squamous carcinomas of the larynx and hypopharynx were pathologically verified and analyzed by polymerase chain reaction for detection of HPV DNA. Charts were independently reviewed and coded until final analysis. Setting: The University of Texas M. D. Anderson Cancer Center, Houston, a tertiary cancer referral center. Results: DNA was successfully extracted from 65 archival patient samples (83%). The mean (±SEM) duration of follow-up for these patients was 42±21 months. Thirty specimens (46%) exhibited detectable HPV DNA. Detection of HPV was significantly related to decreased survival, independent of disease stage. Log rank testing revealed that HPV detection, pathologic vascular invasion, and nodal status were the most significant predictors of death of disease. Conclusions: Laryngeal and hypopharyngeal carcinomas with detectable HPV may represent a biologically distinct subset of tumors that carry a poorer prognosis than do cancers with no detectable HPV.",

author = "Clayman, {Gary L} and Stewart, {Michael G.} and Weber, {Randal S.} and El-Naggar, {Adel K.} and Grimm, {Elizabeth A}",

year = "1994",

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doi = "10.1001/archotol.1994.01880310047009",

language = "English (US)",

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T1 - Human Papillomavirus in Laryngeal and Hypopharyngeal Carcinomas

T2 - Relationship to Survival

AU - Clayman, Gary L

AU - Stewart, Michael G.

AU - Weber, Randal S.

AU - El-Naggar, Adel K.

AU - Grimm, Elizabeth A

PY - 1994/7

Y1 - 1994/7

N2 - Objective: To determine the relationship between human papillomavirus (HPV) DNA detection in upper aerodigestive tract malignancies and patient outcome. Design: Archival paraffin-embedded specimens from 78 previously untreated patients with squamous carcinomas of the larynx and hypopharynx were pathologically verified and analyzed by polymerase chain reaction for detection of HPV DNA. Charts were independently reviewed and coded until final analysis. Setting: The University of Texas M. D. Anderson Cancer Center, Houston, a tertiary cancer referral center. Results: DNA was successfully extracted from 65 archival patient samples (83%). The mean (±SEM) duration of follow-up for these patients was 42±21 months. Thirty specimens (46%) exhibited detectable HPV DNA. Detection of HPV was significantly related to decreased survival, independent of disease stage. Log rank testing revealed that HPV detection, pathologic vascular invasion, and nodal status were the most significant predictors of death of disease. Conclusions: Laryngeal and hypopharyngeal carcinomas with detectable HPV may represent a biologically distinct subset of tumors that carry a poorer prognosis than do cancers with no detectable HPV.

AB - Objective: To determine the relationship between human papillomavirus (HPV) DNA detection in upper aerodigestive tract malignancies and patient outcome. Design: Archival paraffin-embedded specimens from 78 previously untreated patients with squamous carcinomas of the larynx and hypopharynx were pathologically verified and analyzed by polymerase chain reaction for detection of HPV DNA. Charts were independently reviewed and coded until final analysis. Setting: The University of Texas M. D. Anderson Cancer Center, Houston, a tertiary cancer referral center. Results: DNA was successfully extracted from 65 archival patient samples (83%). The mean (±SEM) duration of follow-up for these patients was 42±21 months. Thirty specimens (46%) exhibited detectable HPV DNA. Detection of HPV was significantly related to decreased survival, independent of disease stage. Log rank testing revealed that HPV detection, pathologic vascular invasion, and nodal status were the most significant predictors of death of disease. Conclusions: Laryngeal and hypopharyngeal carcinomas with detectable HPV may represent a biologically distinct subset of tumors that carry a poorer prognosis than do cancers with no detectable HPV.

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Human Papillomavirus in Laryngeal and Hypopharyngeal Carcinomas: Relationship to Survival

Abstract

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