Abstract
The association between human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC) has been recognized for over three decades. Recently, multiple meta-analyses have drawn upon existing literature to assess the strength of the HPV-ESCC linkage. Here, we review these analyses and attempt to provide a clinically-relevant overview of HPV infection in ESCC. HPV-ESCC detection rates are highly variable across studies. Geographic location likely accounts for a majority of the variation in HPV prevalence, with high-incidence regions including Asia reporting significantly higher HPV-ESCC infection rates compared with low-incidence regions such as Europe, North America, and Oceania. Based on our examination of existing data, the current literature does not support the notion that HPV is a prominent carcinogen in ESCC. We conclude that there is no basis to change the current clinical approach to ESCC patients with respect to tumor HPV status.
Original language | English (US) |
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Pages (from-to) | 287-295 |
Number of pages | 9 |
Journal | Journal of Gastrointestinal Oncology |
Volume | 6 |
Issue number | 3 |
DOIs | |
State | Published - 2015 |
Externally published | Yes |
Keywords
- Esophageal cancer
- Human papillomavirus (HPV)
- P16/INK4A
- Squamous cell carcinoma
ASJC Scopus subject areas
- Oncology
- Gastroenterology