@article{4a1f07fb088f45b3bfe8d1e5be7f9dfe,
title = "Human sebaceous tumors harbor inactivating mutations in LEF1",
abstract = "We found that one-third of human sebaceous tumors examined had double-nucleotide substitutions in the same LEF1 allele, irrespective of DNA mismatch repair status. The mutations impaired both LEF1 binding to β-catenin and transcriptional activation, and are the first tumor-associated mutations that inactivate Wnt signaling. Mutant LEF1 not only inhibited expression of β-catenin target genes but also stimulated expression of sebocyte markers, suggesting that it may determine the differentiated characteristics of sebaceous tumors.",
author = "Hikaru Takeda and Stephen Lyle and Lazar, {Alexander J.F.} and Zouboulis, {Christos C.} and Ian Smyth and Watt, {Fiona M.}",
note = "Funding Information: We are grateful to the Cancer Research UK (CR-UK) Equipment Park staff for technical assistance with sequencing. We thank P. Bates and B. Ponder for comments, and M. van de Wetering and C. Lo Celso for reagents. This work was supported by CR-UK (to H.T., I.S. and F.M.W.), US National Institutes of Health grant AR02179 (to S.L.), Harvard Skin Disease Research Center grant P30AR042689 (to A.J.F.L.) and a Uehara Memorial Foundation Fellowship (to H.T.). C.C.Z.{\textquoteright}s contribution to this work was to provide SZ95 cells; he is a co-author under the terms of a Materials Transfer Agreement with F.M.W.",
year = "2006",
month = apr,
doi = "10.1038/nm1386",
language = "English (US)",
volume = "12",
pages = "395--397",
journal = "Nature medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "4",
}