TY - JOUR
T1 - Hyper-CVAD and high-dose methotrexate/cytarabine followed by stem-cell transplantation
T2 - An active regimen for aggressive mantle-cell lymphoma
AU - Khouri, Issa F.
AU - Romaguera, Jorge
AU - Kantarjian, Hagop
AU - Palmer, J. Lynn
AU - Pugh, William C.
AU - Korbling, Martin
AU - Hagemeister, Fredrick
AU - Samuels, Barry
AU - Rodriguez, Alma
AU - Giralt, Sergio
AU - Younes, Anas
AU - Przepiorka, Donna
AU - Claxton, David
AU - Cabanillas, Fernando
AU - Champlin, Richard
PY - 1998/12
Y1 - 1998/12
N2 - Purpose: Diffuse and nodular forms of mantle-cell lymphoma (MCL) are consistently associated with poor prognosis. In an effort to improve the outcome, we adopted a treatment plan that consisted of four courses of fractionated cyclophosphamide (CY) 1,800 mg/m2 administered with doxorubicin (DOX), vincristine (VCR), and dexamethasone (Hyper-CVAD) that alternated with high-dose methotrexate (MTX) and cytarabine (Ara-C). After four courses, patients were consolidated with high-dose CY, total-body irradiation, and autologous or allogeneic blood or marrow stem-cell transplantation. Patients and Methods: Forty-five patients were enrolled; 25 patients were previously untreated, 43 patients had Ann Arbor stage IV disease, and 42 patients had marrow involvement. Forty-one patients had diffuse histology, two patients had nodular, and two patients had blastic variants. Results: Hyper-CVAD/MTX- Ara-C induced a response rate of 93.5% (complete response [CR], 38%; partial response [PR], 55.5%) after four cycles of pretransplantation induction chemotherapy. All patients who went on to undergo transplantation achieved CRs. For the 25 previously untreated patients, the overall survival (os) and event-free survival (EFS) rates at 3 years were 92% (95% confidence interval [Cl], 80 to 100) and 72% (95% Cl, 45 to 98) compared with 25% (95% Cl, 12 to 62; P = .005) and 17% (95% Cl, 10 to 43; P = .007), respectively, for the previously treated patients. When compared with a historic control group who received a CY, DOX, VCR, and prednisone (CHOP)-like regimen, untreated patients in the study had a 3-year EF5 rate of 72% versus 28% (P = .0001) and a better OS rate (92% v 56%; P = .05). Treatment-related death occurred in five patients: all were previously treated and two received allogeneic transplants. Conclusion: The Hyper-CVAD/MTX-Ara-C program followed by stem- cell transplantation is a promising new therapy for previously untreated patients with MCL.
AB - Purpose: Diffuse and nodular forms of mantle-cell lymphoma (MCL) are consistently associated with poor prognosis. In an effort to improve the outcome, we adopted a treatment plan that consisted of four courses of fractionated cyclophosphamide (CY) 1,800 mg/m2 administered with doxorubicin (DOX), vincristine (VCR), and dexamethasone (Hyper-CVAD) that alternated with high-dose methotrexate (MTX) and cytarabine (Ara-C). After four courses, patients were consolidated with high-dose CY, total-body irradiation, and autologous or allogeneic blood or marrow stem-cell transplantation. Patients and Methods: Forty-five patients were enrolled; 25 patients were previously untreated, 43 patients had Ann Arbor stage IV disease, and 42 patients had marrow involvement. Forty-one patients had diffuse histology, two patients had nodular, and two patients had blastic variants. Results: Hyper-CVAD/MTX- Ara-C induced a response rate of 93.5% (complete response [CR], 38%; partial response [PR], 55.5%) after four cycles of pretransplantation induction chemotherapy. All patients who went on to undergo transplantation achieved CRs. For the 25 previously untreated patients, the overall survival (os) and event-free survival (EFS) rates at 3 years were 92% (95% confidence interval [Cl], 80 to 100) and 72% (95% Cl, 45 to 98) compared with 25% (95% Cl, 12 to 62; P = .005) and 17% (95% Cl, 10 to 43; P = .007), respectively, for the previously treated patients. When compared with a historic control group who received a CY, DOX, VCR, and prednisone (CHOP)-like regimen, untreated patients in the study had a 3-year EF5 rate of 72% versus 28% (P = .0001) and a better OS rate (92% v 56%; P = .05). Treatment-related death occurred in five patients: all were previously treated and two received allogeneic transplants. Conclusion: The Hyper-CVAD/MTX-Ara-C program followed by stem- cell transplantation is a promising new therapy for previously untreated patients with MCL.
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U2 - 10.1200/JCO.1998.16.12.3803
DO - 10.1200/JCO.1998.16.12.3803
M3 - Article
C2 - 9850025
AN - SCOPUS:0032422078
SN - 0732-183X
VL - 16
SP - 3803
EP - 3809
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 12
ER -