TY - JOUR
T1 - Hyperpolarized Porous Silicon Nanoparticles
T2 - Potential Theragnostic Material for 29Si Magnetic Resonance Imaging
AU - Seo, Hyeonglim
AU - Choi, Ikjang
AU - Whiting, Nicholas
AU - Hu, Jingzhe
AU - Luu, Quy Son
AU - Pudakalakatti, Shivanand
AU - McCowan, Caitlin
AU - Kim, Yaewon
AU - Zacharias, Niki
AU - Lee, Seunghyun
AU - Bhattacharya, Pratip
AU - Lee, Youngbok
N1 - Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/9/5
Y1 - 2018/9/5
N2 - Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for 29Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their 29Si MR signals; the particles demonstrated long 29Si spin-lattice relaxation (T1) times (∼25 mins), which suggests potential applicability for medical imaging. Furthermore, 29Si hyperpolarization levels were sufficient to allow 29Si MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes in vivo.
AB - Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for 29Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their 29Si MR signals; the particles demonstrated long 29Si spin-lattice relaxation (T1) times (∼25 mins), which suggests potential applicability for medical imaging. Furthermore, 29Si hyperpolarization levels were sufficient to allow 29Si MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes in vivo.
KW - DNP
KW - Si hyperpolarization
KW - molecular magnetic resonance imaging
KW - porous silicon nanoparticles
KW - theragnostic material
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U2 - 10.1002/cphc.201800461
DO - 10.1002/cphc.201800461
M3 - Article
C2 - 29779258
AN - SCOPUS:85052784335
SN - 1439-4235
VL - 19
SP - 2143
EP - 2147
JO - ChemPhysChem
JF - ChemPhysChem
IS - 17
ER -