Hypodermoclysis for the administration of fluids and narcotic analgesics in patients with advanced cancer

Eduardo Bruera; Mary Ann Legris; Norma Kuehn; Melvin J. Miller

doi:10.1016/0885-3924(90)90014-B

Hypodermoclysis for the administration of fluids and narcotic analgesics in patients with advanced cancer

Eduardo Bruera, Mary Ann Legris, Norma Kuehn, Melvin J. Miller

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Fifty-eight consecutive patients with advanced cancer who required parenteral hydration were treated with hypodermoclysis. A solution of two-thirds 5% dextrose and one third saline was used in all cases at a rate of 20-100 cc/hr, with 750 units of hyaluronidase per liter, and 20-40 mEq KCl/L were administered in all patients. In 38 patients, morphine (21 cases) or hydromorphone (17 cases) were added. The mean duration of infusion and volume were 14 ± 9 days and 1.3 ± 0.8 L/day, respectively (range, 0.5-3 L/day). Mean dose of KCl was 25 ± 8 mEq/L. The reason for discontinuation was death in 43 cases, oral hydration in 12 cases, and need for fluid restriction in 3 cases. Toxicity consisted in local infection in two cases and bruising in two cases. We conclude that hypodermoclysis is a safe and effective method of hydration in patients with advanced cancer.

Original language	English (US)
Pages (from-to)	218-220
Number of pages	3
Journal	Journal of pain and symptom management
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/0885-3924(90)90014-B
State	Published - Aug 1990
Externally published	Yes

Keywords

Hydration
cancer
electrolytes
hypodermoclysis
narcotics
subcutaneous

ASJC Scopus subject areas

General Nursing
Clinical Neurology
Anesthesiology and Pain Medicine

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10.1016/0885-3924(90)90014-B

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title = "Hypodermoclysis for the administration of fluids and narcotic analgesics in patients with advanced cancer",

abstract = "Fifty-eight consecutive patients with advanced cancer who required parenteral hydration were treated with hypodermoclysis. A solution of two-thirds 5% dextrose and one third saline was used in all cases at a rate of 20-100 cc/hr, with 750 units of hyaluronidase per liter, and 20-40 mEq KCl/L were administered in all patients. In 38 patients, morphine (21 cases) or hydromorphone (17 cases) were added. The mean duration of infusion and volume were 14 ± 9 days and 1.3 ± 0.8 L/day, respectively (range, 0.5-3 L/day). Mean dose of KCl was 25 ± 8 mEq/L. The reason for discontinuation was death in 43 cases, oral hydration in 12 cases, and need for fluid restriction in 3 cases. Toxicity consisted in local infection in two cases and bruising in two cases. We conclude that hypodermoclysis is a safe and effective method of hydration in patients with advanced cancer.",

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author = "Eduardo Bruera and Legris, {Mary Ann} and Norma Kuehn and Miller, {Melvin J.}",

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AU - Bruera, Eduardo

AU - Legris, Mary Ann

AU - Kuehn, Norma

AU - Miller, Melvin J.

PY - 1990/8

Y1 - 1990/8

N2 - Fifty-eight consecutive patients with advanced cancer who required parenteral hydration were treated with hypodermoclysis. A solution of two-thirds 5% dextrose and one third saline was used in all cases at a rate of 20-100 cc/hr, with 750 units of hyaluronidase per liter, and 20-40 mEq KCl/L were administered in all patients. In 38 patients, morphine (21 cases) or hydromorphone (17 cases) were added. The mean duration of infusion and volume were 14 ± 9 days and 1.3 ± 0.8 L/day, respectively (range, 0.5-3 L/day). Mean dose of KCl was 25 ± 8 mEq/L. The reason for discontinuation was death in 43 cases, oral hydration in 12 cases, and need for fluid restriction in 3 cases. Toxicity consisted in local infection in two cases and bruising in two cases. We conclude that hypodermoclysis is a safe and effective method of hydration in patients with advanced cancer.

AB - Fifty-eight consecutive patients with advanced cancer who required parenteral hydration were treated with hypodermoclysis. A solution of two-thirds 5% dextrose and one third saline was used in all cases at a rate of 20-100 cc/hr, with 750 units of hyaluronidase per liter, and 20-40 mEq KCl/L were administered in all patients. In 38 patients, morphine (21 cases) or hydromorphone (17 cases) were added. The mean duration of infusion and volume were 14 ± 9 days and 1.3 ± 0.8 L/day, respectively (range, 0.5-3 L/day). Mean dose of KCl was 25 ± 8 mEq/L. The reason for discontinuation was death in 43 cases, oral hydration in 12 cases, and need for fluid restriction in 3 cases. Toxicity consisted in local infection in two cases and bruising in two cases. We conclude that hypodermoclysis is a safe and effective method of hydration in patients with advanced cancer.

KW - Hydration

KW - cancer

KW - electrolytes

KW - hypodermoclysis

KW - narcotics

KW - subcutaneous

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Hypodermoclysis for the administration of fluids and narcotic analgesics in patients with advanced cancer

Abstract

Keywords

ASJC Scopus subject areas

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