@inbook{b1c4f5241e144d5fbfc1b2c017b66e93,
title = "Hypoxia and the Unfolded Protein Response",
abstract = "Tumor hypoxia refers to the development of regions within solid tumors in which the oxygen concentration is lower (0-3%) compared to that in most normal tissues (4-9%) (Vaupel and Hockel, 2000). Considerable experimental and clinical evidence exists supporting the notion that hypoxia fundamentally alters the physiology of the tumor towards a more aggressive phenotype (Hockel and Vaupel, 2001). Therefore, delineating the mechanisms by which hypoxia affects tumor physiology at the cellular and molecular levels will be crucial for a better understanding of tumor development and metastasis and for designing better antitumor modalities.",
author = "Constantinos Koumenis and Meixia Bi and Jiangbin Ye and Douglas Feldman and Koong, {Albert C.}",
year = "2007",
month = dec,
day = "1",
doi = "10.1016/S0076-6879(07)35014-3",
language = "English (US)",
isbn = "9780123739704",
volume = "435",
series = "Methods in Enzymology",
pages = "275--293",
editor = "Helmut Sies and Bernhard Brune",
booktitle = "Oxygen Biology and Hypoxia",
}