TY - JOUR
T1 - Hypoxia-induced and stress-specific changes in chromatin structure and function
AU - Johnson, Amber Buescher
AU - Barton, Michelle Craig
N1 - Funding Information:
We apologize to our colleagues whose work we failed to cite, due to space limitations. Work in our laboratory is supported by grant GM053686 from the National Institutes of Health to MCB; and ABJ is a trainee supported by grant T32-CA009299 from the National Institutes of Health.
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Cellular adaptation to stress relies on specific, regulated responses to evoke changes in gene expression. Stresses such as hypoxia, heat shock, oxidative stress and DNA-damage activate signaling cascades that ultimately lead to either induction or repression of stress-responsive genes. In this review, we concentrate on the mechanisms by which stress-induced signaling promotes alterations in chromatin structure, whether the read-out is activation or repression of transcription. Specific alterations in chromatin are highly regulated and dictated by the type of imposed stress. Our primary focus is on the types of chromatin alterations that occur under hypoxic conditions, which exist within a majority of tumors, and to compare these to changes in chromatin structure that occur in response to a wide variety of cellular stresses.
AB - Cellular adaptation to stress relies on specific, regulated responses to evoke changes in gene expression. Stresses such as hypoxia, heat shock, oxidative stress and DNA-damage activate signaling cascades that ultimately lead to either induction or repression of stress-responsive genes. In this review, we concentrate on the mechanisms by which stress-induced signaling promotes alterations in chromatin structure, whether the read-out is activation or repression of transcription. Specific alterations in chromatin are highly regulated and dictated by the type of imposed stress. Our primary focus is on the types of chromatin alterations that occur under hypoxic conditions, which exist within a majority of tumors, and to compare these to changes in chromatin structure that occur in response to a wide variety of cellular stresses.
KW - Cellular stress
KW - Chromatin structure
KW - Hypoxia
KW - Oxidative stress
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U2 - 10.1016/j.mrfmmm.2006.10.007
DO - 10.1016/j.mrfmmm.2006.10.007
M3 - Article
C2 - 17292925
AN - SCOPUS:34147161066
SN - 0027-5107
VL - 618
SP - 149
EP - 162
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
IS - 1-2
ER -