Identification of a CD133-CD55-population functions as a fetal common skeletal progenitor

Lihong Weng; Xingbin Hu; Bijender Kumar; Mayra Garcia; Ivan Todorov; Xiaoman Jung; Guido Marcucci; Stephen J. Forman; Ching Cheng Chen

doi:10.1038/srep38632

Identification of a CD133-CD55-population functions as a fetal common skeletal progenitor

Lihong Weng, Xingbin Hu, Bijender Kumar, Mayra Garcia, Ivan Todorov, Xiaoman Jung, Guido Marcucci, Stephen J. Forman, Ching Cheng Chen

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

In this study, we identified a CD105+CD90.1-CD133-CD55-(CD133-CD55-) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133-CD55-common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal progenitors suggesting they function as the fetal common skeletal progenitor. Suppression of CXCL12 and Kitl expression in CD133-CD55-common progenitors severely disrupted the BM niche formation but not bone generation. Thus, CD133-CD55-common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow.

Original language	English (US)
Article number	38632
Journal	Scientific reports
Volume	6
DOIs	https://doi.org/10.1038/srep38632
State	Published - Dec 8 2016
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1038/srep38632

Cite this

@article{bf12cd74e89b4f7fbd47862d3a73af11,

title = "Identification of a CD133-CD55-population functions as a fetal common skeletal progenitor",

abstract = "In this study, we identified a CD105+CD90.1-CD133-CD55-(CD133-CD55-) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133-CD55-common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal progenitors suggesting they function as the fetal common skeletal progenitor. Suppression of CXCL12 and Kitl expression in CD133-CD55-common progenitors severely disrupted the BM niche formation but not bone generation. Thus, CD133-CD55-common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow.",

author = "Lihong Weng and Xingbin Hu and Bijender Kumar and Mayra Garcia and Ivan Todorov and Xiaoman Jung and Guido Marcucci and Forman, {Stephen J.} and Chen, {Ching Cheng}",

note = "Funding Information: Tis study was supported in part by grants from the Children Leukemia Research Association, the TinkCure! Foundation, the Margaret E. Early Medical Research Trust, American Cancer Society Grant 128766-RSG-15-162 and the NIH grant HL087936 (to C.-C.C.). X.H. was supported by a California Institute for Regenerative Medicine (CIRM) training grant. Publisher Copyright: {\textcopyright} The Author(s) 2016.",

year = "2016",

month = dec,

day = "8",

doi = "10.1038/srep38632",

language = "English (US)",

volume = "6",

journal = "Scientific reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Identification of a CD133-CD55-population functions as a fetal common skeletal progenitor

AU - Weng, Lihong

AU - Hu, Xingbin

AU - Kumar, Bijender

AU - Garcia, Mayra

AU - Todorov, Ivan

AU - Jung, Xiaoman

AU - Marcucci, Guido

AU - Forman, Stephen J.

AU - Chen, Ching Cheng

N1 - Funding Information: Tis study was supported in part by grants from the Children Leukemia Research Association, the TinkCure! Foundation, the Margaret E. Early Medical Research Trust, American Cancer Society Grant 128766-RSG-15-162 and the NIH grant HL087936 (to C.-C.C.). X.H. was supported by a California Institute for Regenerative Medicine (CIRM) training grant. Publisher Copyright: © The Author(s) 2016.

PY - 2016/12/8

Y1 - 2016/12/8

N2 - In this study, we identified a CD105+CD90.1-CD133-CD55-(CD133-CD55-) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133-CD55-common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal progenitors suggesting they function as the fetal common skeletal progenitor. Suppression of CXCL12 and Kitl expression in CD133-CD55-common progenitors severely disrupted the BM niche formation but not bone generation. Thus, CD133-CD55-common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow.

AB - In this study, we identified a CD105+CD90.1-CD133-CD55-(CD133-CD55-) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133-CD55-common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal progenitors suggesting they function as the fetal common skeletal progenitor. Suppression of CXCL12 and Kitl expression in CD133-CD55-common progenitors severely disrupted the BM niche formation but not bone generation. Thus, CD133-CD55-common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow.

UR - http://www.scopus.com/inward/record.url?scp=85002856493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85002856493&partnerID=8YFLogxK

U2 - 10.1038/srep38632

DO - 10.1038/srep38632

M3 - Article

C2 - 27929130

AN - SCOPUS:85002856493

SN - 2045-2322

VL - 6

JO - Scientific reports

JF - Scientific reports

M1 - 38632

ER -

Identification of a CD133-CD55-population functions as a fetal common skeletal progenitor

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this