TY - JOUR
T1 - Identification of markers predictive for response to induction chemotherapy in patients with sinonasal undifferentiated carcinoma
AU - Takahashi, Yoko
AU - Gleber-Netto, Frederico O.
AU - Bell, D.
AU - Roberts, Dianna
AU - Xie, Tong Xin
AU - Abdelmeguid, Ahmed S.
AU - Pickering, Curtis
AU - Myers, Jeffrey N.
AU - Hanna, Ehab Y.
N1 - Funding Information:
We thank Barbara DeLeon, Allison Lane, Bobby Banay, Yunxia Guo, and Bridget Reeves for administrative support and Donald R Norwood in the Department of Scientific Publications at MD Anderson for editing the manuscript. This work was supported by various sinus cancer research funds and MD Anderson Start-Up Funds. The datasets used and/analyzed during the current study are available from the corresponding author on reasonable request.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/10
Y1 - 2019/10
N2 - Objectives: Sinonasal undifferentiated carcinoma (SNUC) is a rare, highly aggressive cancer. Despite aggressive multimodal therapy, its prognosis remains poor. Because of its locally advanced nature and high propensity for distant metastasis, we frequently use induction chemotherapy before definitive therapy in patients with SNUC. However, about 30% of patients do not respond to induction chemotherapy, and lack of response is associated with a poor survival rate. Therefore, in this study, we performed gene expression analysis of SNUC samples to identify prognostic markers for induction chemotherapy response. Materials and methods: Formalin-fixed, paraffin-embedded SNUC tumor samples from previously untreated patients harvested before induction chemotherapy were used. Gene expression was performed using an oncology gene expression panel. Results: We identified 34 differentially expressed genes that distinguish the responders from the non-responders. Pathway analysis using these genes revealed alteration of multiple pathways between the two groups. Of these 34 genes, 24 distinguished between these two groups. Additionally, 16 gene pairs were associated with response to induction therapy. Conclusion: We identified genes predictive of SNUC response to induction chemotherapy and pathways potentially associated with treatment outcome. This is the first report of identification of predictive biomarkers for response of SNUC to induction chemotherapy, and it may help us develop therapeutic strategies to improve the treatment outcomes of non-responders.
AB - Objectives: Sinonasal undifferentiated carcinoma (SNUC) is a rare, highly aggressive cancer. Despite aggressive multimodal therapy, its prognosis remains poor. Because of its locally advanced nature and high propensity for distant metastasis, we frequently use induction chemotherapy before definitive therapy in patients with SNUC. However, about 30% of patients do not respond to induction chemotherapy, and lack of response is associated with a poor survival rate. Therefore, in this study, we performed gene expression analysis of SNUC samples to identify prognostic markers for induction chemotherapy response. Materials and methods: Formalin-fixed, paraffin-embedded SNUC tumor samples from previously untreated patients harvested before induction chemotherapy were used. Gene expression was performed using an oncology gene expression panel. Results: We identified 34 differentially expressed genes that distinguish the responders from the non-responders. Pathway analysis using these genes revealed alteration of multiple pathways between the two groups. Of these 34 genes, 24 distinguished between these two groups. Additionally, 16 gene pairs were associated with response to induction therapy. Conclusion: We identified genes predictive of SNUC response to induction chemotherapy and pathways potentially associated with treatment outcome. This is the first report of identification of predictive biomarkers for response of SNUC to induction chemotherapy, and it may help us develop therapeutic strategies to improve the treatment outcomes of non-responders.
KW - Chemoresistance
KW - Comprehensive gene expression study
KW - Induction chemotherapy
KW - Predictive markers
KW - Sinonasal undifferentiated carcinoma
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U2 - 10.1016/j.oraloncology.2019.07.028
DO - 10.1016/j.oraloncology.2019.07.028
M3 - Article
C2 - 31421472
AN - SCOPUS:85070524564
SN - 1368-8375
VL - 97
SP - 56
EP - 61
JO - Oral Oncology
JF - Oral Oncology
ER -