IgG4-related disease in the abdomen and pelvis: atypical findings, pitfalls, and mimics

Yanqiu Zheng, Khaled M. Elsayes, Christy Waranch, Amr Abdelaziz, Christine O. Menias, Kumar Sandrasegaran, Akram M. Shaaban, Ayman H. Gaballah

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

IgG4-related disease (IgG4-RD) is a systemic, autoimmune, fibroinflammatory disease that can cause multi-organ damage. Although there have been many trials and studies since its recognition in 2003, there is still much that is unknown. Furthermore, IgG4-RD can affect any organ in the body and often has many mimics and alternative diagnoses, which can make for a challenging workup. Imaging plays a substantial role in the diagnosis of IgG4-RD and is often the first occasion where IgG4-RD comes into consideration. Thus, knowledge about the imaging findings of various manifestations of IgG4-RD can aid in the diagnosis and have a significant impact on patient management. In this article, we review the wide array of imaging findings, both typical and atypical, as well as possible mimics of IgG4-RD in the abdomen and pelvis.

Original languageEnglish (US)
Pages (from-to)2485-2499
Number of pages15
JournalAbdominal Radiology
Volume45
Issue number8
DOIs
StatePublished - Aug 1 2020

Keywords

  • Autoimmune pancreatitis
  • IgG4
  • IgG4 vasculitis
  • IgG4-related disease
  • Retroperitoneal fibrosis
  • Sclerosing cholangitis
  • Sclerosing mesenteritis

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

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