IL-11Rα: A novel target for the treatment of osteosarcoma

Valerae O. Lewis

doi:10.1007/978-3-319-04843-7_15

IL-11Rα: A novel target for the treatment of osteosarcoma

Valerae O. Lewis

Surgical Oncology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Recent advances have shown that cell surface receptors are expressed differentially in normal and pathological conditions. Novel organ specifi c and disease specifi c proteins expressed on tumor vasculature have been identifi ed by in vivo phage display technology and the diversity of the tumor-associated vasculature has provided the basis for the development of targeted therapeutics. Investigators recently screened a phage display library in a human cancer patient. An IL-11 mimic phage displaying the cyclic peptide CGRRAGGSC (single letter amino acid code) specifi cally bound to immobilized IL-11Rα. It has been demonstrated that the expression of the IL-11Rα is increased in several other types of tumors including osteosarcoma. The ability to selectively target the IL-11Rα may provide an alternative treatment of for a disease where new treatment options are truly needed.

Original language	English (US)
Pages (from-to)	285-289
Number of pages	5
Journal	Advances in experimental medicine and biology
Volume	804
DOIs	https://doi.org/10.1007/978-3-319-04843-7_15
State	Published - 2014

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-3-319-04843-7_15

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title = "IL-11Rα: A novel target for the treatment of osteosarcoma",

abstract = "Recent advances have shown that cell surface receptors are expressed differentially in normal and pathological conditions. Novel organ specifi c and disease specifi c proteins expressed on tumor vasculature have been identifi ed by in vivo phage display technology and the diversity of the tumor-associated vasculature has provided the basis for the development of targeted therapeutics. Investigators recently screened a phage display library in a human cancer patient. An IL-11 mimic phage displaying the cyclic peptide CGRRAGGSC (single letter amino acid code) specifi cally bound to immobilized IL-11Rα. It has been demonstrated that the expression of the IL-11Rα is increased in several other types of tumors including osteosarcoma. The ability to selectively target the IL-11Rα may provide an alternative treatment of for a disease where new treatment options are truly needed.",

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N2 - Recent advances have shown that cell surface receptors are expressed differentially in normal and pathological conditions. Novel organ specifi c and disease specifi c proteins expressed on tumor vasculature have been identifi ed by in vivo phage display technology and the diversity of the tumor-associated vasculature has provided the basis for the development of targeted therapeutics. Investigators recently screened a phage display library in a human cancer patient. An IL-11 mimic phage displaying the cyclic peptide CGRRAGGSC (single letter amino acid code) specifi cally bound to immobilized IL-11Rα. It has been demonstrated that the expression of the IL-11Rα is increased in several other types of tumors including osteosarcoma. The ability to selectively target the IL-11Rα may provide an alternative treatment of for a disease where new treatment options are truly needed.

AB - Recent advances have shown that cell surface receptors are expressed differentially in normal and pathological conditions. Novel organ specifi c and disease specifi c proteins expressed on tumor vasculature have been identifi ed by in vivo phage display technology and the diversity of the tumor-associated vasculature has provided the basis for the development of targeted therapeutics. Investigators recently screened a phage display library in a human cancer patient. An IL-11 mimic phage displaying the cyclic peptide CGRRAGGSC (single letter amino acid code) specifi cally bound to immobilized IL-11Rα. It has been demonstrated that the expression of the IL-11Rα is increased in several other types of tumors including osteosarcoma. The ability to selectively target the IL-11Rα may provide an alternative treatment of for a disease where new treatment options are truly needed.

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JO - Advances in experimental medicine and biology

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ER -

IL-11Rα: A novel target for the treatment of osteosarcoma

Abstract

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