@inproceedings{ec44dd09201a4b66883a7cf9d4762c11,
title = "Image-guided fluorescence tomography in ti{\ss}ue phantom models of oral cancer",
abstract = "Current intraoperative methods to a{\ss}e{\ss} tumor invasion depth in mucosal oral cancer provide limited real-time information. The advent of targeted fluorescence contrast agents for head and neck cancer is a promising innovation, but surgical imaging systems typically provide only two-dimensional views. Here, we investigate the use of an image-guided fluorescence tomography (igFT) system to estimate the depth of tumor invasion in ti{\ss}ue-simulating oral cancer phantoms. Implementation of non-contact diffuse optical tomography using finite-element software (NIRFAST) is enabled with geometric data from intraoperative cone-beam CT (CBCT) imaging and surgical navigation. The ti{\ss}ue phantoms used gelatin for the background (5% for fat, 10% for muscle) and 2% agar for palpable, tumor-like inclusions. Standard agents were used for absorption (hemoglobin), scattering (Intralipid), fluorescence (indocyanine green), and CT contrast (iohexol). The agar inclusions were formed using 3D printed molds, and positioned at the surface of the gelatin background to mimic mucosal tumor invasion (an {"}iceberg{"} model). Simulations and phantom experiments characterize fluorescence tomography performance acro{\ss} a range of tumor invasion depths. To aid surgical visualization, the fluorescence volume is converted to a colored surface indicating tumor depth, and overlaid on the navigated endoscopic video. Clinical studies are nece{\ss}ary to a{\ss}e{\ss} in vivo performance and intraoperative workflow.",
keywords = "Diffuse optical tomography, Fluorescence tomography, Optical phantoms, Oral cancer, Surgical navigation",
author = "Daly, {Michael J.} and Jacqueline Fleisig and Harley Chan and Marco Ferrari and Catriona Douglas and Wilson, {Brian C.} and Jaffray, {David A.} and Irish, {Jonathan C.}",
note = "Funding Information: This work is supported by the Raymond Ng & Wendy Chui Foundation for Innovation in Otolaryngology – Head & Neck Surgery (Dept. of Otolaryngology – Head & Neck Surgery, University of Toronto) and the Garron Family GTx Surgery – Engineering Fund (Princess Margaret Cancer Foundation). Thank you also to the open-source software community including NIRFAST (Dartmouth College / University of Birmingham), 3D Slicer (Brigham and Women{\textquoteright}s Hospital), ITK-SNAP (University of Pennsylvania), VTK (Kitware) and IGSTK (Children{\textquoteright}s National / Kitware). Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Molecular-Guided Surgery: Molecules, Devices, and Applications VI 2020 ; Conference date: 01-02-2020 Through 02-02-2020",
year = "2020",
doi = "10.1117/12.2547348",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Sylvain Gioux and Gibbs, {Summer L.} and Pogue, {Brian W.}",
booktitle = "Molecular-Guided Surgery",
}