Image quality improvements with time-of-flight positron emission tomography for molecular imaging

Ravindra M. Manjeshwar; Yiping Shao; Floris P. Jansen

doi:10.1109/ICASSP.2005.1416438

Image quality improvements with time-of-flight positron emission tomography for molecular imaging

Ravindra M. Manjeshwar, Yiping Shao, Floris P. Jansen

Imaging Physics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

9 Scopus citations

Abstract

The renewed interest in Time Of Flight (TOF) PET is being driven by the development of detector technology and the growth of new molecular imaging applications. In this study we performed Monte Carlo simulations to quantify image quality improvements as a function of timing resolution for imaging scenarios that mimic whole body and brain imaging. We implemented an iterative image reconstruction algorithm that incorporated time-of-flight information. Image quality, as measured through contrast and noise metrics, consistently improved with improved timing resolution. We simulated and compared a conventional PET scanner with a TOF-PET scanner with 200 ps timing resolution. For lesions embedded in 40cm and 20 cm cylindrical objects, lesion contrast improved by a factor of 3.4 and 2.3, respectively. TOF-PET holds the potential for significantly improved imaging over conventional PET scanners of equivalent sensitivity.

Original language	English (US)
Title of host publication	2005 IEEE ICASSP '05 - Proc. - Design and Implementation of Signal Proces.Syst.,Indust. Technol. Track,Machine Learning for Signal Proces. Education, Spec. Sessions
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	V853-V856
ISBN (Print)	0780388747, 9780780388741
DOIs	https://doi.org/10.1109/ICASSP.2005.1416438
State	Published - 2005
Event	2005 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP '05 - Philadelphia, PA, United States Duration: Mar 18 2005 → Mar 23 2005

Publication series

Name	ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings
Volume	V
ISSN (Print)	1520-6149

Other

Other	2005 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP '05
Country/Territory	United States
City	Philadelphia, PA
Period	3/18/05 → 3/23/05

ASJC Scopus subject areas

Software
Signal Processing
Electrical and Electronic Engineering

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10.1109/ICASSP.2005.1416438

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Manjeshwar, R. M., Shao, Y., & Jansen, F. P. (2005). Image quality improvements with time-of-flight positron emission tomography for molecular imaging. In 2005 IEEE ICASSP '05 - Proc. - Design and Implementation of Signal Proces.Syst.,Indust. Technol. Track,Machine Learning for Signal Proces. Education, Spec. Sessions (pp. V853-V856). Article 1416438 (ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings; Vol. V). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICASSP.2005.1416438

Image quality improvements with time-of-flight positron emission tomography for molecular imaging. / Manjeshwar, Ravindra M.; Shao, Yiping; Jansen, Floris P.
2005 IEEE ICASSP '05 - Proc. - Design and Implementation of Signal Proces.Syst.,Indust. Technol. Track,Machine Learning for Signal Proces. Education, Spec. Sessions. Institute of Electrical and Electronics Engineers Inc., 2005. p. V853-V856 1416438 (ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings; Vol. V).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Manjeshwar, RM, Shao, Y & Jansen, FP 2005, Image quality improvements with time-of-flight positron emission tomography for molecular imaging. in 2005 IEEE ICASSP '05 - Proc. - Design and Implementation of Signal Proces.Syst.,Indust. Technol. Track,Machine Learning for Signal Proces. Education, Spec. Sessions., 1416438, ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings, vol. V, Institute of Electrical and Electronics Engineers Inc., pp. V853-V856, 2005 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP '05, Philadelphia, PA, United States, 3/18/05. https://doi.org/10.1109/ICASSP.2005.1416438

Manjeshwar RM, Shao Y, Jansen FP. Image quality improvements with time-of-flight positron emission tomography for molecular imaging. In 2005 IEEE ICASSP '05 - Proc. - Design and Implementation of Signal Proces.Syst.,Indust. Technol. Track,Machine Learning for Signal Proces. Education, Spec. Sessions. Institute of Electrical and Electronics Engineers Inc. 2005. p. V853-V856. 1416438. (ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings). doi: 10.1109/ICASSP.2005.1416438

Manjeshwar, Ravindra M. ; Shao, Yiping ; Jansen, Floris P. / Image quality improvements with time-of-flight positron emission tomography for molecular imaging. 2005 IEEE ICASSP '05 - Proc. - Design and Implementation of Signal Proces.Syst.,Indust. Technol. Track,Machine Learning for Signal Proces. Education, Spec. Sessions. Institute of Electrical and Electronics Engineers Inc., 2005. pp. V853-V856 (ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings).

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Image quality improvements with time-of-flight positron emission tomography for molecular imaging

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