Imaging and dosimetry of 99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors

Hiroaki Kurihara; David J. Yang; Massimo Cristofanilli; William D. Erwin; Dong Fang Yu; Saady Kohanim; Richard Mendez; E. Edmund Kim

doi:10.1016/j.apradiso.2008.01.012

Imaging and dosimetry of ^99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors

Hiroaki Kurihara, David J. Yang, Massimo Cristofanilli, William D. Erwin, Dong Fang Yu, Saady Kohanim, Richard Mendez, E. Edmund Kim

Imaging Physics

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Background: Early detection of cellular events is important to predict the outcome of the patients. This study was aimed to use ^99mTc EC-annexin V to image tumor cells undergoing apoptosis. Methods: In 10 patients with breast cancer, scintigraphic images and dosimetric estimates were obtained after administering ^99mTc EC-annexin V. Results: Nine of the 10 cases showed detectable ^99mTc EC-annexin V uptake in tumor. Higher values of T/N ratios are associated with patient after treatment. Conclusions: Apoptosis can be quantified using ^99mTc EC-annexin V.

Original language	English (US)
Pages (from-to)	1175-1182
Number of pages	8
Journal	Applied Radiation and Isotopes
Volume	66
Issue number	9
DOIs	https://doi.org/10.1016/j.apradiso.2008.01.012
State	Published - Sep 2008

Keywords

Annexin V
Apoptosis
Breast cancer
Tc

ASJC Scopus subject areas

Radiation

Access to Document

10.1016/j.apradiso.2008.01.012

Cite this

@article{a721cc8388c2461a86483c0aa2022766,

title = "Imaging and dosimetry of 99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors",

abstract = "Background: Early detection of cellular events is important to predict the outcome of the patients. This study was aimed to use 99mTc EC-annexin V to image tumor cells undergoing apoptosis. Methods: In 10 patients with breast cancer, scintigraphic images and dosimetric estimates were obtained after administering 99mTc EC-annexin V. Results: Nine of the 10 cases showed detectable 99mTc EC-annexin V uptake in tumor. Higher values of T/N ratios are associated with patient after treatment. Conclusions: Apoptosis can be quantified using 99mTc EC-annexin V.",

keywords = "Annexin V, Apoptosis, Breast cancer, Tc",

author = "Hiroaki Kurihara and Yang, {David J.} and Massimo Cristofanilli and Erwin, {William D.} and Yu, {Dong Fang} and Saady Kohanim and Richard Mendez and Kim, {E. Edmund}",

note = "Funding Information: The authors wish to thank Charhonda Chilton for her secretarial support. This work was supported in part by the John S. Dunn Foundation and Cell and Point Biotechnology Company (LS01-212). The animal research was supported by M.D. Anderson Cancer Center (CORE) Grant NIH CA-16672.",

year = "2008",

month = sep,

doi = "10.1016/j.apradiso.2008.01.012",

language = "English (US)",

volume = "66",

pages = "1175--1182",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Limited",

number = "9",

}

TY - JOUR

T1 - Imaging and dosimetry of 99mTc EC annexin V

T2 - Preliminary clinical study targeting apoptosis in breast tumors

AU - Kurihara, Hiroaki

AU - Yang, David J.

AU - Cristofanilli, Massimo

AU - Erwin, William D.

AU - Yu, Dong Fang

AU - Kohanim, Saady

AU - Mendez, Richard

AU - Kim, E. Edmund

N1 - Funding Information: The authors wish to thank Charhonda Chilton for her secretarial support. This work was supported in part by the John S. Dunn Foundation and Cell and Point Biotechnology Company (LS01-212). The animal research was supported by M.D. Anderson Cancer Center (CORE) Grant NIH CA-16672.

PY - 2008/9

Y1 - 2008/9

N2 - Background: Early detection of cellular events is important to predict the outcome of the patients. This study was aimed to use 99mTc EC-annexin V to image tumor cells undergoing apoptosis. Methods: In 10 patients with breast cancer, scintigraphic images and dosimetric estimates were obtained after administering 99mTc EC-annexin V. Results: Nine of the 10 cases showed detectable 99mTc EC-annexin V uptake in tumor. Higher values of T/N ratios are associated with patient after treatment. Conclusions: Apoptosis can be quantified using 99mTc EC-annexin V.

AB - Background: Early detection of cellular events is important to predict the outcome of the patients. This study was aimed to use 99mTc EC-annexin V to image tumor cells undergoing apoptosis. Methods: In 10 patients with breast cancer, scintigraphic images and dosimetric estimates were obtained after administering 99mTc EC-annexin V. Results: Nine of the 10 cases showed detectable 99mTc EC-annexin V uptake in tumor. Higher values of T/N ratios are associated with patient after treatment. Conclusions: Apoptosis can be quantified using 99mTc EC-annexin V.

KW - Annexin V

KW - Apoptosis

KW - Breast cancer

KW - Tc

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DO - 10.1016/j.apradiso.2008.01.012

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C2 - 18308577

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SN - 0969-8043

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EP - 1182

JO - Applied Radiation and Isotopes

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