@article{3823f00c7beb475cb0891255402e40b6,
title = "Imaging of tau pathology in a tauopathy mouse model and in alzheimer patients compared to normal controls",
abstract = "Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer@s disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions in brains of living patients with AD or non-AD tauopathies and animal models of these disorders. Invivo optical and positron emission tomographic (PET) imaging of a transgenic mouse model demonstrated sensitive detection oftau inclusions by PBBs. A pyridinated PBB, [11C]PBB3, was next applied in a clinical PET study, and its robust signal in the AD hippocampus wherein tau pathology is enriched contrasted strikingly with that of a senile plaque radioligand, [11C]Pittsburgh Compound-B ([11C]PIB). [11C]PBB3-PET data were also consistent with the spreading of tau pathology with AD progression. Furthermore, increased [11C]PBB3 signals were found in a corticobasal syndrome patient negative for [11C]PIB-PET",
author = "Masahiro Maruyama and Hitoshi Shimada and Tetsuya Suhara and Hitoshi Shinotoh and Bin Ji and Jun Maeda and Zhang, {Ming Rong} and Trojanowski, {John Q.} and Lee, {Virginia M.Y.} and Maiko Ono and Kazuto Masamoto and Harumasa Takano and Naruhiko Sahara and Nobuhisa Iwata and Nobuyuki Okamura and Shozo Furumoto and Yukitsuka Kudo and Qing Chang and Saido, {Takaomi C.} and Akihiko Takashima and Jada Lewis and Jang, {Ming Kuei} and Ichio Aoki and Hiroshi Ito and Makoto Higuchi",
note = "Funding Information: The authors thank Mr. T. Minamihisamatsu and Mr. Y. Matsuba for technical assistance, the staff of the Molecular Probe Group, National Institute of Radiological Sciences, for support with radiosynthesis, Dr. Y. Yoshiyama at National Hospital Organization Chiba-East Hospital for his support on clinical PET studies, and Dr. T. Iwatsubo at the University of Tokyo and Dr. H. Inoue at Kyoto University for their critical discussions. This work was supported in part by grants from the National Institute on Aging of the National Institutes of Health (AG10124 and AG17586) (to J.Q.T. and V. M.-Y.L.), Grants-in-Aid for Japan Advanced Molecular Imaging Program, Young Scientists (21791158) (to M.M.), Scientific Research (B) (23390235) (to M.H.), Core Research for Evolutional Science and Technology (to T.S.), Scientific Research on Innovative Areas (“Brain Environment”) (23111009) (to M.H.) from the Ministry of Education, Culture, Sports, Science and Technology, Japan, Thomas H. Maren Junior Investigator Fund from College of Medicine, University of Florida (to N.S.), and research fund of Belfer Neurodegeneration Consortium (to Q.C. and M.-K.J.). M.M., H. Shimada, T.S., M.-R.Z., and M.H. are named as inventors on a patent application 0749006WO1, claiming subject matter related to the results described in this paper. ",
year = "2013",
month = sep,
day = "18",
doi = "10.1016/j.neuron.2013.07.037",
language = "English (US)",
volume = "79",
pages = "1094--1108",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",
}