Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography

Geng Ku; Xueding Wang; Xueyi Xie; George Stoica; Lihong V. Wang

doi:10.1364/AO.44.000770

Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography

Geng Ku, Xueding Wang, Xueyi Xie, George Stoica, Lihong V. Wang

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

211 Scopus citations

Abstract

Green laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser were employed as irradiation sources for photoacoustic tomography (PAT). The vascular structure of the brain was imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. The photoacoustic images of rat brain tumors in this study clearly reveal the angiogenesis that is associated with tumors. Brain tumors can be identified based on the distorted vascular architecture of brain tumorigenesis and related vascular changes, such as hemorrhage. This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research.

Original language	English (US)
Pages (from-to)	770-775
Number of pages	6
Journal	Applied Optics
Volume	44
Issue number	5
DOIs	https://doi.org/10.1364/AO.44.000770
State	Published - Feb 10 2005

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Engineering (miscellaneous)
Electrical and Electronic Engineering

Access to Document

10.1364/AO.44.000770

Cite this

@article{d4a90b6b62694fb4bd6f13050e637d7c,

title = "Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography",

abstract = "Green laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser were employed as irradiation sources for photoacoustic tomography (PAT). The vascular structure of the brain was imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. The photoacoustic images of rat brain tumors in this study clearly reveal the angiogenesis that is associated with tumors. Brain tumors can be identified based on the distorted vascular architecture of brain tumorigenesis and related vascular changes, such as hemorrhage. This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research.",

author = "Geng Ku and Xueding Wang and Xueyi Xie and George Stoica and Wang, {Lihong V.}",

year = "2005",

month = feb,

day = "10",

doi = "10.1364/AO.44.000770",

language = "English (US)",

volume = "44",

pages = "770--775",

journal = "Applied Optics",

issn = "1559-128X",

publisher = "The Optical Society",

number = "5",

}

TY - JOUR

T1 - Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography

AU - Ku, Geng

AU - Wang, Xueding

AU - Xie, Xueyi

AU - Stoica, George

AU - Wang, Lihong V.

PY - 2005/2/10

Y1 - 2005/2/10

N2 - Green laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser were employed as irradiation sources for photoacoustic tomography (PAT). The vascular structure of the brain was imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. The photoacoustic images of rat brain tumors in this study clearly reveal the angiogenesis that is associated with tumors. Brain tumors can be identified based on the distorted vascular architecture of brain tumorigenesis and related vascular changes, such as hemorrhage. This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research.

AB - Green laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser were employed as irradiation sources for photoacoustic tomography (PAT). The vascular structure of the brain was imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. The photoacoustic images of rat brain tumors in this study clearly reveal the angiogenesis that is associated with tumors. Brain tumors can be identified based on the distorted vascular architecture of brain tumorigenesis and related vascular changes, such as hemorrhage. This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research.

UR - http://www.scopus.com/inward/record.url?scp=14844311203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14844311203&partnerID=8YFLogxK

U2 - 10.1364/AO.44.000770

DO - 10.1364/AO.44.000770

M3 - Article

C2 - 15751858

AN - SCOPUS:14844311203

SN - 1559-128X

VL - 44

SP - 770

EP - 775

JO - Applied Optics

JF - Applied Optics

IS - 5

ER -

Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this